Hemolytic anemias due to disorders of red cell membrane skeleton.

D. Bossi, M. Russo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

During the past 10 years, knowledge of the composition, function and supramolecular assembly of the red cell membrane has been greatly expanded by progress in molecular and cell biology. Detailed information on the organization of membrane cytoskeletal proteins and their molecular characterization has allowed us to correlate a number of protein abnormalities with clinical symptoms that are peculiar to hereditary hemolytic anemias (HHA). In particular, three general principles emerge that can help us to understand the pathogenetic mechanisms of HHA: (a) protein-protein and protein-lipid interactions greatly influence the correct assembly of the membrane skeleton; (b) the red blood cell (RBC) membrane skeleton mostly determines the shape (discocyte), deformability (rheologic properties) and durability (half-life and resistence to shear stress) of the erythrocytes; (c) changes in cytoskeletal composition and/or organization can produce alterations in all of the above properties, and therefore they are responsible for the onset of the hemolytic damage.

Original languageEnglish
Pages (from-to)171-188
Number of pages18
JournalMolecular Aspects of Medicine
Volume17
Issue number2
Publication statusPublished - Apr 1996

Fingerprint

Hemolytic Anemia
Cell membranes
Skeleton
Congenital Hemolytic Anemia
Cell Membrane
Proteins
Erythrocytes
Cytology
Membranes
Molecular biology
Cytoskeletal Proteins
Formability
Chemical analysis
Half-Life
Cell Biology
Shear stress
Molecular Biology
Membrane Proteins
Durability
Blood

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine

Cite this

Hemolytic anemias due to disorders of red cell membrane skeleton. / Bossi, D.; Russo, M.

In: Molecular Aspects of Medicine, Vol. 17, No. 2, 04.1996, p. 171-188.

Research output: Contribution to journalArticle

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