TY - JOUR
T1 - Hemolytic uremic syndrome in adults
AU - Ponticelli, C.
AU - Rivolta, E.
AU - Imbasciati, E.
AU - Rossi, E.
AU - Mannucci, P. M.
PY - 1980
Y1 - 1980
N2 - The long-term clinical course of 11 adults with hemolytic-uremic syndrome (HUS) is reported. All patients were treated with heparin and antiplatelet drugs, and 10 required dialysis. One patient died after 38 days; the others recovered from anuria after 7-400 days. One patient was resubmitted to regular dialysis 5 yr later, and another died because of cerebral hemorrhage. Among the remaining 8 patients, 4 show renal failure and 4 have normal renal function after 1-10 yr of observation. All but 3 require vigorous antihypertensive therapy. It is concluded that in adults with HUS (1) recovery may occur even after a prolonged anuria; (2) severe hypertension and progressive renal failure may appear later in apparently recovered patients; and (3) heparin and antiplatelet drugs seem to be beneficial in reversing acute renal failure.
AB - The long-term clinical course of 11 adults with hemolytic-uremic syndrome (HUS) is reported. All patients were treated with heparin and antiplatelet drugs, and 10 required dialysis. One patient died after 38 days; the others recovered from anuria after 7-400 days. One patient was resubmitted to regular dialysis 5 yr later, and another died because of cerebral hemorrhage. Among the remaining 8 patients, 4 show renal failure and 4 have normal renal function after 1-10 yr of observation. All but 3 require vigorous antihypertensive therapy. It is concluded that in adults with HUS (1) recovery may occur even after a prolonged anuria; (2) severe hypertension and progressive renal failure may appear later in apparently recovered patients; and (3) heparin and antiplatelet drugs seem to be beneficial in reversing acute renal failure.
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U2 - 10.1001/archinte.140.3.353
DO - 10.1001/archinte.140.3.353
M3 - Article
C2 - 7362354
VL - 140
SP - 353
EP - 357
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
SN - 0003-9926
IS - 3
ER -