Hemolytic Uremic Syndrome in Adults

Claudio Ponticelli, Emilio Rivolta, Enrico Imbasciati, Edoardo Rossi, Pier Mannuccio Mannucci

Research output: Contribution to journalArticle

Abstract

The long-term clinical course of 11 adults with hemolytic-uremic syndrome (HUS) is reported. All patients were treated with heparin and antiplatelet drugs, and ten required dialysis. One patient died after 38 days; the others recovered from anuria after seven to 400 days. One patient was resubmitted to regular dialysis five years later, and another died because of cerebral hemorrhage. Among the remaining eight patients, four show renal failure and four have normal renal function after one to ten years of observation. All but three require vigorous antihypertensive therapy. It is concluded that in adults with HUS (1) recovery may occur even after a prolonged anuria; (2) severe hypertension and progressive renal failure may appear later in apparently recovered patients; and (3) heparin and antiplatelet drugs seem to be beneficial in reversing acute renal failure.

Original languageEnglish
Pages (from-to)353-357
Number of pages5
JournalArchives of Internal Medicine
Volume140
Issue number3
DOIs
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Internal Medicine

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