Hemoperfusion with a new anion exchange resin corrects the metabolic alkalosis in pyloric stenosis: An experimental demonstration

S. Faenza, M. Balestri, G. Martinelli, M. Spighi, M. Fini, R. Giardino, L. Coli, G. Cianciolo, S. Stefoni, V. Bonomini

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Abstract

An experimental model of hypertrophic pyloric stenosis was made by suture of the pyloric wall and gastrostomy in 10 rabbits under general anesthesia. Blood sampling indicated severe alkalosis and hypochloremia 3 h 30 min after surgery. To correct the derangement, we tested an ion exchange resin (Dowex SAR), coated with a methacrylic hydrogel. A cartridge containing 18 g of this resin was inserted in an extracorporeal circuit. This chloride charged resin achieved uptake of HCO3 - ions, and elution of Cl- ions. The electrolytic balance was fully restored after 10 min of treatment.

Original languageEnglish
Pages (from-to)677-680
Number of pages4
JournalInternational Journal of Artificial Organs
Volume15
Issue number11
Publication statusPublished - 1992

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ASJC Scopus subject areas

  • Biophysics

Cite this

Faenza, S., Balestri, M., Martinelli, G., Spighi, M., Fini, M., Giardino, R., Coli, L., Cianciolo, G., Stefoni, S., & Bonomini, V. (1992). Hemoperfusion with a new anion exchange resin corrects the metabolic alkalosis in pyloric stenosis: An experimental demonstration. International Journal of Artificial Organs, 15(11), 677-680.