TY - JOUR
T1 - Hemophilia and nonprogressing human immunodeficiency virus type I infection
AU - Vicenzi, Elisa
AU - Bagnarelli, Patrizia
AU - Santagostino, Elena
AU - Ghezzi, Silvia
AU - Alfano, Massimo
AU - Sinnone, Marina S.
AU - Fabio, Giovanna
AU - Turchetto, Lucia
AU - Moretti, Gianluca
AU - Lazzarin, Adriano
AU - Mantovani, Alberto
AU - Mannucci, Pier Mannuccio
AU - Clementi, Massimo
AU - Gringeri, Alessandro
AU - Poli, Guido
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Seven of 112 hemophiliacs infected with human immunodeficiency virus type-1 (HIV-1) before 1986 through contaminated plasma products are currently healthy, with CD4 T-cell counts above 500 cells/μL, and have never received antiretroviral therapy (long-term nonprogressors [LTNPs]). Seven age and sex- matched hemophiliacs infected in the same period but who have progressive HIV disease (progressors) and one additional slow-progressing individual were also studied. One hundred-fold, 20-fold, and 10-fold lower levels of full- length HIV RNA in plasma, peripheral blood mononuclear cells (PBMCs), and proviral DNA in PBMCs, respectively, were found in LTNPs compared with progressors. Plasma and cell-associated HIV RNA and proviral DNA were lower in LTNPs who tested negative for viral isolation from PBMCs or who were positive only after removal of CD8+ cells. No substantial differences were observed in the in vitro production of chemokines including RANTES, MIP-1α, MIP-1β, MCP-1, and interleukin-8 (IL-8) in supernatants of activated PBMCs or CD8-depleted PBMCs of LTNPs, even when HIV isolation was simultaneously accomplished exclusively after removal of CD8+ cells. Low levels of HIV load and replication in peripheral blood are the strongest correlates of nonprogression in this small number of infected hemophiliacs.
AB - Seven of 112 hemophiliacs infected with human immunodeficiency virus type-1 (HIV-1) before 1986 through contaminated plasma products are currently healthy, with CD4 T-cell counts above 500 cells/μL, and have never received antiretroviral therapy (long-term nonprogressors [LTNPs]). Seven age and sex- matched hemophiliacs infected in the same period but who have progressive HIV disease (progressors) and one additional slow-progressing individual were also studied. One hundred-fold, 20-fold, and 10-fold lower levels of full- length HIV RNA in plasma, peripheral blood mononuclear cells (PBMCs), and proviral DNA in PBMCs, respectively, were found in LTNPs compared with progressors. Plasma and cell-associated HIV RNA and proviral DNA were lower in LTNPs who tested negative for viral isolation from PBMCs or who were positive only after removal of CD8+ cells. No substantial differences were observed in the in vitro production of chemokines including RANTES, MIP-1α, MIP-1β, MCP-1, and interleukin-8 (IL-8) in supernatants of activated PBMCs or CD8-depleted PBMCs of LTNPs, even when HIV isolation was simultaneously accomplished exclusively after removal of CD8+ cells. Low levels of HIV load and replication in peripheral blood are the strongest correlates of nonprogression in this small number of infected hemophiliacs.
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M3 - Article
C2 - 8978292
AN - SCOPUS:0031019493
VL - 89
SP - 191
EP - 200
JO - Blood
JF - Blood
SN - 0006-4971
IS - 1
ER -