Hemorheological, hemostatic and metabolic long-term (24 months) study of young women taking a monophasic pill containing gestodene and ethinylestradiol

Objective: To investigate the hemoreologic, hemostatic and metabolic effects of a monophasic low-dose oral contraceptive. Methods: Twenty healthy young women desiring hormonal contraception were studied before, during and after a 2 year course of a monophasic oral contraceptive containing gestodene 75 μg and ethinylestradiol 30 μg. Twenty-nine matched healthy young women were chosen as the control group. Results: No differences in any of the variables evaluated (body mass index, blood pressure, erythrocyte deformability, concentrations of triglycerides, total HDL, LDL and VLDL cholesterol, non-esterified fatty acids, serum lipoproteins VLDL, LDL, HDL and apolipoproteins A, A₁ and B, fibrinogen, fibronectin, von Willebrand factor antigen, α₂-macroglobulin, antithrombin III, prolactin) were demonstrated between the women taking the monophasic pill and the control group. Conclusion: Oral contraception with the monophasic gestodene and ethinylestradiol combination may be a safe long-term hormonal contraceptive method for young women and prevent the development of cardiovascular complications.