Objective: To investigate the hemoreologic, hemostatic and metabolic effects of a monophasic low-dose oral contraceptive. Methods: Twenty healthy young women desiring hormonal contraception were studied before, during and after a 2 year course of a monophasic oral contraceptive containing gestodene 75 μg and ethinylestradiol 30 μg. Twenty-nine matched healthy young women were chosen as the control group. Results: No differences in any of the variables evaluated (body mass index, blood pressure, erythrocyte deformability, concentrations of triglycerides, total HDL, LDL and VLDL cholesterol, non-esterified fatty acids, serum lipoproteins VLDL, LDL, HDL and apolipoproteins A, A1 and B, fibrinogen, fibronectin, von Willebrand factor antigen, α2-macroglobulin, antithrombin III, prolactin) were demonstrated between the women taking the monophasic pill and the control group. Conclusion: Oral contraception with the monophasic gestodene and ethinylestradiol combination may be a safe long-term hormonal contraceptive method for young women and prevent the development of cardiovascular complications.
|Number of pages||7|
|Journal||Italian Journal of Gynaecology and Obstetrics|
|Publication status||Published - 1993|
ASJC Scopus subject areas
- Obstetrics and Gynaecology