Hemorheological, hemostatic and metabolic long-term (24 months) study of young women taking a monophasic pill containing gestodene and ethinylestradiol

S. B. Solerte, M. Fioravanti, A. Spinillo, E. Capuzzo, A. Iasci, M. Mastrolilli, P. Berard, P. Reboli, E. Ferrari, S. Guaschino

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate the hemoreologic, hemostatic and metabolic effects of a monophasic low-dose oral contraceptive. Methods: Twenty healthy young women desiring hormonal contraception were studied before, during and after a 2 year course of a monophasic oral contraceptive containing gestodene 75 μg and ethinylestradiol 30 μg. Twenty-nine matched healthy young women were chosen as the control group. Results: No differences in any of the variables evaluated (body mass index, blood pressure, erythrocyte deformability, concentrations of triglycerides, total HDL, LDL and VLDL cholesterol, non-esterified fatty acids, serum lipoproteins VLDL, LDL, HDL and apolipoproteins A, A1 and B, fibrinogen, fibronectin, von Willebrand factor antigen, α2-macroglobulin, antithrombin III, prolactin) were demonstrated between the women taking the monophasic pill and the control group. Conclusion: Oral contraception with the monophasic gestodene and ethinylestradiol combination may be a safe long-term hormonal contraceptive method for young women and prevent the development of cardiovascular complications.

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalItalian Journal of Gynaecology and Obstetrics
Volume5
Issue number3
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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