Abstract
Background It has been clearly demonstrated that hypertension and one of its main evoked effects, cardiac hypertrophy, are independent risk factors for ischemic stroke. However, the ischemic brain lesions can further be affected by a second wave of injury characterized by hemorrhagic transformation (HT) of the primary ischemic lesion, which significantly aggravates the clinical outcome. So far, the risk factors that could affect such a transition in hypertensive patients are still unclear. Methods In this study, we investigated whether in hypertensive patients the concomitant presence of cardiac hypertrophy can affect the transition of ischemic brain lesions toward HT. Results Our analysis was focused on a population of hypertensive patients admitted to our Acute Stroke Unit. The hypertensives with acute ischemic stroke suffering of HT were 18% of the sample. In these latter, the prevalence of cardiac hypertrophy was significantly lower than in those spared by HT as also shown by the levels of left ventricular mass index (LVMI) that were significantly higher in patients spared by HT. More important, cardiac hypertrophy was protective even from symptomatic HT. Conclusion Here we show that hypertensive patients with cardiac hypertrophy have less probability to develop HT during an acute episode of ischemic stroke. These results could help to identify patients with lower risk of spontaneous HT and that could have better beneficial effects from thrombolytic therapy during acute ischemic stroke.
| Original language | English |
|---|---|
| Pages (from-to) | 362-366 |
| Number of pages | 5 |
| Journal | International Journal of Cardiology |
| Volume | 219 |
| DOIs | |
| Publication status | Published - Sep 15 2016 |
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Keywords
- Cardiac hypertrophy
- Hemorrhagic transformation
- Hypertension
- Stroke
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Hemorrhagic transformation of acute ischemic stroke is limited in hypertensive patients with cardiac hypertrophy. / Landolfi, Alessandro; Selvetella, Giulio; Cugino, Daniela; Grillea, Giovanni; Maffei, Angelo; Notte, Antonella; Lembo, Giuseppe; Carnevale, Daniela.
In: International Journal of Cardiology, Vol. 219, 15.09.2016, p. 362-366.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hemorrhagic transformation of acute ischemic stroke is limited in hypertensive patients with cardiac hypertrophy
AU - Landolfi, Alessandro
AU - Selvetella, Giulio
AU - Cugino, Daniela
AU - Grillea, Giovanni
AU - Maffei, Angelo
AU - Notte, Antonella
AU - Lembo, Giuseppe
AU - Carnevale, Daniela
PY - 2016/9/15
Y1 - 2016/9/15
N2 - Background It has been clearly demonstrated that hypertension and one of its main evoked effects, cardiac hypertrophy, are independent risk factors for ischemic stroke. However, the ischemic brain lesions can further be affected by a second wave of injury characterized by hemorrhagic transformation (HT) of the primary ischemic lesion, which significantly aggravates the clinical outcome. So far, the risk factors that could affect such a transition in hypertensive patients are still unclear. Methods In this study, we investigated whether in hypertensive patients the concomitant presence of cardiac hypertrophy can affect the transition of ischemic brain lesions toward HT. Results Our analysis was focused on a population of hypertensive patients admitted to our Acute Stroke Unit. The hypertensives with acute ischemic stroke suffering of HT were 18% of the sample. In these latter, the prevalence of cardiac hypertrophy was significantly lower than in those spared by HT as also shown by the levels of left ventricular mass index (LVMI) that were significantly higher in patients spared by HT. More important, cardiac hypertrophy was protective even from symptomatic HT. Conclusion Here we show that hypertensive patients with cardiac hypertrophy have less probability to develop HT during an acute episode of ischemic stroke. These results could help to identify patients with lower risk of spontaneous HT and that could have better beneficial effects from thrombolytic therapy during acute ischemic stroke.
AB - Background It has been clearly demonstrated that hypertension and one of its main evoked effects, cardiac hypertrophy, are independent risk factors for ischemic stroke. However, the ischemic brain lesions can further be affected by a second wave of injury characterized by hemorrhagic transformation (HT) of the primary ischemic lesion, which significantly aggravates the clinical outcome. So far, the risk factors that could affect such a transition in hypertensive patients are still unclear. Methods In this study, we investigated whether in hypertensive patients the concomitant presence of cardiac hypertrophy can affect the transition of ischemic brain lesions toward HT. Results Our analysis was focused on a population of hypertensive patients admitted to our Acute Stroke Unit. The hypertensives with acute ischemic stroke suffering of HT were 18% of the sample. In these latter, the prevalence of cardiac hypertrophy was significantly lower than in those spared by HT as also shown by the levels of left ventricular mass index (LVMI) that were significantly higher in patients spared by HT. More important, cardiac hypertrophy was protective even from symptomatic HT. Conclusion Here we show that hypertensive patients with cardiac hypertrophy have less probability to develop HT during an acute episode of ischemic stroke. These results could help to identify patients with lower risk of spontaneous HT and that could have better beneficial effects from thrombolytic therapy during acute ischemic stroke.
KW - Cardiac hypertrophy
KW - Hemorrhagic transformation
KW - Hypertension
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=84975770546&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975770546&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2016.06.060
DO - 10.1016/j.ijcard.2016.06.060
M3 - Article
AN - SCOPUS:84975770546
VL - 219
SP - 362
EP - 366
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -