The authors explored the behavior of hemostasis in 26 patients suffering from acute flareups of COPD with partial or total respiratory insufficiency. The exploration was repeated after 7 hospital days, when the acute flareup situation was under control. The data obtained during the acute phase indicate activation of hemostasis and an increment of platelet aggregation induced by ADP or collagen is normal. The data obtained at repeated exploration show a nearly complete restoration of normal blood clottability. At the same time, however, the behavior of ADP-induced platelet aggregation suggests that the normal aggregability seen in the earlier phase actually masks a situation of platelet functional deficiency deriving from the underlying respiratory illness; such a deficiency seems to be momentarily corrected by the acute flareup of bronchitis, which acts in this sense as a stimulus.
|Translated title of the contribution||Hemostasis in flareups of chronic obstructive pulmonary disease|
|Title of host publication||Giornale Italiano della Malattie del Torace|
|Number of pages||11|
|Publication status||Published - 1981|
ASJC Scopus subject areas