Fattori dell'emostasi e storia familiare di trombosi in pazienti con infarto del miocardio: studio caso-controllo. I patecipanti al GISSI-2-Efrim.

Translated title of the contribution: Hemostatic factors and family history of thrombosis in patients with a myocardial infarct: a case-control study. The participants in GISSI-2-Efrim. Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico

L. Iacoviello, M. C. Roncaglioni, C. Amore, R. M. Marfisi, A. Celardo, G. Feruglio, M. G. Franzosi, G. Tognoni, A. Maseri, M. B. Donati

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We studied a series of hemostasis factors in a group of patients selected from a cohort of 916 patients affected by MI from the GISSI-2 study population. Following a case-control design, 73 patients with a family history of thrombosis (the presence of at least two first degree relatives affected by MI and/or stroke before 65 years) were matched with MI patients with no family history of thrombosis. Blood collection could be performed 6 +/- 1 months after the acute phase following MI in 53 pairs of such patients. The presence of mixed disulphides (MDS) was significantly higher in patients with family history than in controls; MDS were detected in 7 cases and only in 1 control. No difference was found in contrast in the distribution of fibrinogen, factor VII, factor VIII, vWF, protein C, protein S, AT III, HC II, PAI-1, lipoprotein (a). Nevertheless, independently from the family history, in the whole population of MI patients studied, 21 cases of suspected deficiency of protein C were found. Sixteen out of 53 patients with family history of MI and/or stroke had a family history of MI only. In patients with family history of MI the t-PA antigen levels were significantly lower than in the control group (7.5 +/- 4.4 vs 11.1 +/- 3.5 ng/ml, t = -2.6, p <0.02). In the whole population of MI patients and in patients with a family history of thrombosis t-PA antigen was positively correlated with PAI-1 antigen and vWF. The correlation with PAI-1 was lost in patients with family history of MI.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageItalian
Pages (from-to)769-776
Number of pages8
JournalGiornale Italiano di Cardiologia
Volume25
Issue number6
Publication statusPublished - Jun 1995

Fingerprint

Hemostatics
Case-Control Studies
Thrombosis
Myocardial Infarction
Plasminogen Activator Inhibitor 1
Antigens
Disulfides
Stroke
Protein C Deficiency
Population
Lipoprotein(a)
Factor VII
Protein S
Factor VIII
Protein C
Hemostasis
Fibrinogen

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Fattori dell'emostasi e storia familiare di trombosi in pazienti con infarto del miocardio : studio caso-controllo. I patecipanti al GISSI-2-Efrim. / Iacoviello, L.; Roncaglioni, M. C.; Amore, C.; Marfisi, R. M.; Celardo, A.; Feruglio, G.; Franzosi, M. G.; Tognoni, G.; Maseri, A.; Donati, M. B.

In: Giornale Italiano di Cardiologia, Vol. 25, No. 6, 06.1995, p. 769-776.

Research output: Contribution to journalArticle

@article{051088ae633f429dab3b6c66d04fb0ac,
title = "Fattori dell'emostasi e storia familiare di trombosi in pazienti con infarto del miocardio: studio caso-controllo. I patecipanti al GISSI-2-Efrim.",
abstract = "We studied a series of hemostasis factors in a group of patients selected from a cohort of 916 patients affected by MI from the GISSI-2 study population. Following a case-control design, 73 patients with a family history of thrombosis (the presence of at least two first degree relatives affected by MI and/or stroke before 65 years) were matched with MI patients with no family history of thrombosis. Blood collection could be performed 6 +/- 1 months after the acute phase following MI in 53 pairs of such patients. The presence of mixed disulphides (MDS) was significantly higher in patients with family history than in controls; MDS were detected in 7 cases and only in 1 control. No difference was found in contrast in the distribution of fibrinogen, factor VII, factor VIII, vWF, protein C, protein S, AT III, HC II, PAI-1, lipoprotein (a). Nevertheless, independently from the family history, in the whole population of MI patients studied, 21 cases of suspected deficiency of protein C were found. Sixteen out of 53 patients with family history of MI and/or stroke had a family history of MI only. In patients with family history of MI the t-PA antigen levels were significantly lower than in the control group (7.5 +/- 4.4 vs 11.1 +/- 3.5 ng/ml, t = -2.6, p <0.02). In the whole population of MI patients and in patients with a family history of thrombosis t-PA antigen was positively correlated with PAI-1 antigen and vWF. The correlation with PAI-1 was lost in patients with family history of MI.(ABSTRACT TRUNCATED AT 250 WORDS)",
author = "L. Iacoviello and Roncaglioni, {M. C.} and C. Amore and Marfisi, {R. M.} and A. Celardo and G. Feruglio and Franzosi, {M. G.} and G. Tognoni and A. Maseri and Donati, {M. B.}",
year = "1995",
month = "6",
language = "Italian",
volume = "25",
pages = "769--776",
journal = "Giornale Italiano di Cardiologia",
issn = "0046-5968",
publisher = "Societa Italiana di Cardiologia",
number = "6",

}

TY - JOUR

T1 - Fattori dell'emostasi e storia familiare di trombosi in pazienti con infarto del miocardio

T2 - studio caso-controllo. I patecipanti al GISSI-2-Efrim.

AU - Iacoviello, L.

AU - Roncaglioni, M. C.

AU - Amore, C.

AU - Marfisi, R. M.

AU - Celardo, A.

AU - Feruglio, G.

AU - Franzosi, M. G.

AU - Tognoni, G.

AU - Maseri, A.

AU - Donati, M. B.

PY - 1995/6

Y1 - 1995/6

N2 - We studied a series of hemostasis factors in a group of patients selected from a cohort of 916 patients affected by MI from the GISSI-2 study population. Following a case-control design, 73 patients with a family history of thrombosis (the presence of at least two first degree relatives affected by MI and/or stroke before 65 years) were matched with MI patients with no family history of thrombosis. Blood collection could be performed 6 +/- 1 months after the acute phase following MI in 53 pairs of such patients. The presence of mixed disulphides (MDS) was significantly higher in patients with family history than in controls; MDS were detected in 7 cases and only in 1 control. No difference was found in contrast in the distribution of fibrinogen, factor VII, factor VIII, vWF, protein C, protein S, AT III, HC II, PAI-1, lipoprotein (a). Nevertheless, independently from the family history, in the whole population of MI patients studied, 21 cases of suspected deficiency of protein C were found. Sixteen out of 53 patients with family history of MI and/or stroke had a family history of MI only. In patients with family history of MI the t-PA antigen levels were significantly lower than in the control group (7.5 +/- 4.4 vs 11.1 +/- 3.5 ng/ml, t = -2.6, p <0.02). In the whole population of MI patients and in patients with a family history of thrombosis t-PA antigen was positively correlated with PAI-1 antigen and vWF. The correlation with PAI-1 was lost in patients with family history of MI.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - We studied a series of hemostasis factors in a group of patients selected from a cohort of 916 patients affected by MI from the GISSI-2 study population. Following a case-control design, 73 patients with a family history of thrombosis (the presence of at least two first degree relatives affected by MI and/or stroke before 65 years) were matched with MI patients with no family history of thrombosis. Blood collection could be performed 6 +/- 1 months after the acute phase following MI in 53 pairs of such patients. The presence of mixed disulphides (MDS) was significantly higher in patients with family history than in controls; MDS were detected in 7 cases and only in 1 control. No difference was found in contrast in the distribution of fibrinogen, factor VII, factor VIII, vWF, protein C, protein S, AT III, HC II, PAI-1, lipoprotein (a). Nevertheless, independently from the family history, in the whole population of MI patients studied, 21 cases of suspected deficiency of protein C were found. Sixteen out of 53 patients with family history of MI and/or stroke had a family history of MI only. In patients with family history of MI the t-PA antigen levels were significantly lower than in the control group (7.5 +/- 4.4 vs 11.1 +/- 3.5 ng/ml, t = -2.6, p <0.02). In the whole population of MI patients and in patients with a family history of thrombosis t-PA antigen was positively correlated with PAI-1 antigen and vWF. The correlation with PAI-1 was lost in patients with family history of MI.(ABSTRACT TRUNCATED AT 250 WORDS)

UR - http://www.scopus.com/inward/record.url?scp=0029317805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029317805&partnerID=8YFLogxK

M3 - Articolo

C2 - 7649426

AN - SCOPUS:0029317805

VL - 25

SP - 769

EP - 776

JO - Giornale Italiano di Cardiologia

JF - Giornale Italiano di Cardiologia

SN - 0046-5968

IS - 6

ER -