Henle Loop Basement Membrane as Initial Site for Randall Plaque Formation

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Since the early description of Randall plaques in 1937, studies of the pathogenesis of stone formation mainly focused on the chemistry involving salt precipitation and crystallization, rather than tubular and interstitial medullar mechanisms of calcium concentration and supersaturation. In 2003, Bushinsky published a suggestive and inspiring sequence of events aimed to show that the basement membrane of the thin limb of the loop of Henle can be the first site of nucleation, as recently shown by the impressive work by Evan et al. The aim of this minireview is to verify the consistency of the Evan and Bushinsky theory with the current literature in the field.

Original languageEnglish
Pages (from-to)706-711
Number of pages6
JournalAmerican Journal of Kidney Diseases
Volume48
Issue number5
DOIs
Publication statusPublished - Nov 2006

Fingerprint

Loop of Henle
Crystallization
Basement Membrane
Extremities
Salts
Calcium

Keywords

  • hypothesis
  • pathogenesis
  • Urolithiasis

ASJC Scopus subject areas

  • Nephrology

Cite this

Henle Loop Basement Membrane as Initial Site for Randall Plaque Formation. / Sepe, Vincenzo; Adamo, Gabriella; La Fianza, Alfredo; Libetta, Carmelo; Giuliano, Maria G.; Soccio, Grazia; Dal Canton, Antonio.

In: American Journal of Kidney Diseases, Vol. 48, No. 5, 11.2006, p. 706-711.

Research output: Contribution to journalArticle

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