Henoch-Schönlein nephritis

Franco Ferrario, Maria Pia Rastaldi

Research output: Contribution to journalArticle

Abstract

Henoch-Schönlein purpura is a clinical syndrome characterized by the association of skin, joint, and gastrointestinal symptoms. Henoch-Schönlein purpura is characterized by wide-spread vasculitis. Although the clinical symptoms of this disease are characteristic, the diagnosis is not always easy to establish because other forms of systemic vasculitis - mainly the microscopic form of periarteritis nodosa - may mimic the disease. In addition, in contrast to systemic lupus erythematosus, there are no biological test that can identify Henoch-Schönlein purpura with certainty. Immunofluorescence microscopic thechniques have made an important contribution to both the diagnosis and the study of the pathogenesis of the disease, particularly since they have demonstrated the presence of IgA deposits in the gloemeruli and in the vessel walls. These finding not only confirmed the immunologic nature of the pathologic lesions but also drew attention to the remarkable similarity between Henoch-Schönlein purpura nephritis and IgA nephropathy.

Original languageEnglish
Pages (from-to)637-641
Number of pages5
JournalJournal of Nephrology
Volume18
Issue number6
Publication statusPublished - Nov 2005

Keywords

  • Endocapillary proliferation
  • IgA immunodeposits
  • Mesangial proliferation
  • Necrotizing extracapillary proliferation

ASJC Scopus subject areas

  • Nephrology

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