Henoch-Schönlein purpura and drug and vaccine use in childhood

A case-control study

Liviana Da Dalt, Claudia Zerbinati, Maria Stefania Strafella, Salvatore Renna, Laura Riceputi, Pasquale Di Pietro, Paola Barabino, Stefania Scanferla, Umberto Raucci, Nadia Mores, Adele Compagnone, Roberto Da Cas, Francesca Menniti-Ippolito

Research output: Contribution to journalArticle

Abstract

Background: Henoch-Schönlein purpura (HSP) is the most common vasculitis in childhood; nevertheless, its etiology and pathogenesis remain unknown despite the fact that a variety of factors, mainly infectious agents, drugs and vaccines have been suggested as triggers for the disease. The aim of this study was to estimate the association of HSP with drug and vaccine administration in a pediatric population. Methods: An active surveillance on drug and vaccine safety in children is ongoing in 11 clinical centers in Italy. All children hospitalized through the local Paediatric Emergency Department for selected acute clinical conditions of interest were enrolled in the study. Data on drug and vaccine use in children before the onset of symptoms leading to hospitalization were collected by parents interview. A case-control design was applied for risk estimates: exposure in children with HSP, included as cases, was compared with similar exposure in children with gastroduodenal lesions, enrolled as controls. HSP cases were validated according to EULAR/PRINTO/PRES criteria. Validation was conducted retrieving data from individual patient clinical record. Results: During the study period (November 1999-April 2013), 288 cases and 617 controls were included. No increased risk of HSP was estimated for any drug. Among vaccines, measles-mumps-rubella (MMR) vaccine showed an increased risk of HSP (OR 3.4; 95 % CI 1.2-10.0). Conclusions: This study provides further evidence on the possible role of MMR vaccine in HSP occurrence.

Original languageEnglish
Article number60
JournalItalian Journal of Pediatrics
Volume42
Issue number1
DOIs
Publication statusPublished - Jun 18 2016

Fingerprint

Schoenlein-Henoch Purpura
Case-Control Studies
Vaccines
Pharmaceutical Preparations
Measles-Mumps-Rubella Vaccine
Pediatrics
Hospitalized Child
Vasculitis
Italy
Hospital Emergency Service
Hospitalization
Parents
Interviews
Safety
Population

Keywords

  • Adverse drug reaction
  • Children
  • Henoch-Schönlein purpura
  • Vaccine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Da Dalt, L., Zerbinati, C., Strafella, M. S., Renna, S., Riceputi, L., Di Pietro, P., ... Menniti-Ippolito, F. (2016). Henoch-Schönlein purpura and drug and vaccine use in childhood: A case-control study. Italian Journal of Pediatrics, 42(1), [60]. https://doi.org/10.1186/s13052-016-0267-2

Henoch-Schönlein purpura and drug and vaccine use in childhood : A case-control study. / Da Dalt, Liviana; Zerbinati, Claudia; Strafella, Maria Stefania; Renna, Salvatore; Riceputi, Laura; Di Pietro, Pasquale; Barabino, Paola; Scanferla, Stefania; Raucci, Umberto; Mores, Nadia; Compagnone, Adele; Da Cas, Roberto; Menniti-Ippolito, Francesca.

In: Italian Journal of Pediatrics, Vol. 42, No. 1, 60, 18.06.2016.

Research output: Contribution to journalArticle

Da Dalt, L, Zerbinati, C, Strafella, MS, Renna, S, Riceputi, L, Di Pietro, P, Barabino, P, Scanferla, S, Raucci, U, Mores, N, Compagnone, A, Da Cas, R & Menniti-Ippolito, F 2016, 'Henoch-Schönlein purpura and drug and vaccine use in childhood: A case-control study', Italian Journal of Pediatrics, vol. 42, no. 1, 60. https://doi.org/10.1186/s13052-016-0267-2
Da Dalt, Liviana ; Zerbinati, Claudia ; Strafella, Maria Stefania ; Renna, Salvatore ; Riceputi, Laura ; Di Pietro, Pasquale ; Barabino, Paola ; Scanferla, Stefania ; Raucci, Umberto ; Mores, Nadia ; Compagnone, Adele ; Da Cas, Roberto ; Menniti-Ippolito, Francesca. / Henoch-Schönlein purpura and drug and vaccine use in childhood : A case-control study. In: Italian Journal of Pediatrics. 2016 ; Vol. 42, No. 1.
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abstract = "Background: Henoch-Sch{\"o}nlein purpura (HSP) is the most common vasculitis in childhood; nevertheless, its etiology and pathogenesis remain unknown despite the fact that a variety of factors, mainly infectious agents, drugs and vaccines have been suggested as triggers for the disease. The aim of this study was to estimate the association of HSP with drug and vaccine administration in a pediatric population. Methods: An active surveillance on drug and vaccine safety in children is ongoing in 11 clinical centers in Italy. All children hospitalized through the local Paediatric Emergency Department for selected acute clinical conditions of interest were enrolled in the study. Data on drug and vaccine use in children before the onset of symptoms leading to hospitalization were collected by parents interview. A case-control design was applied for risk estimates: exposure in children with HSP, included as cases, was compared with similar exposure in children with gastroduodenal lesions, enrolled as controls. HSP cases were validated according to EULAR/PRINTO/PRES criteria. Validation was conducted retrieving data from individual patient clinical record. Results: During the study period (November 1999-April 2013), 288 cases and 617 controls were included. No increased risk of HSP was estimated for any drug. Among vaccines, measles-mumps-rubella (MMR) vaccine showed an increased risk of HSP (OR 3.4; 95 {\%} CI 1.2-10.0). Conclusions: This study provides further evidence on the possible role of MMR vaccine in HSP occurrence.",
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AU - Renna, Salvatore

AU - Riceputi, Laura

AU - Di Pietro, Pasquale

AU - Barabino, Paola

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AU - Raucci, Umberto

AU - Mores, Nadia

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AU - Da Cas, Roberto

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