Heparin binding haemagglutin as potential diagnostic marker of Mycobacterium bovis

Paola Molicotti, Alessandra Bua, Silvia Ortu, Maura C. Ladu, Giovanni Delogu, Antonio Mura, Leonardo A. Sechi, Giovanni Fadda, Stefania Zanetti

Research output: Contribution to journalArticlepeer-review


In this study, we characterized the humoral responses in cattle of Sardinia. The animals were divided into three groups: 1) 28 cattle infected with Mycobactenum bovis; 2) 48 cattle from herds in which foci of infection was notified; 3) 50 cattle from herds that were TB-free. Levels of IgG antibody were measured against the following antigens of M. tuberculosis: Heparin-Binding-Haemagglutin (HBHA), Ag85B, PPE44, and PE_PGRS33 to investigate their potential to diagnose TB in animals. Our results indicated that HBHA is a potential candidate for the development of a serological assay for rapid diagnosis of cattle infected with M. bovis.

Original languageEnglish
Pages (from-to)423-427
Number of pages5
JournalNew Microbiologica
Issue number3
Publication statusPublished - Jul 2008


  • Bovine tuberculosis
  • HBHA
  • Humoral response
  • Mycobacterium bovis

ASJC Scopus subject areas

  • Microbiology (medical)


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