Heparin infusion facilitates ex vivo spontaneous platelet aggregation in patients with acute myocardial infarction who have undergone thrombolytic therapy

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Abstract

We investigated ex vivo spontaneous platelet aggregation (SPA) in platelet-rich plasma in 37 patients with acute myocardial infarction. It occurred in about 50% of subjects receiving heparin after streptokinase treatment, while it rarely took place in patients who did not receive either streptokinase or heparin and in those treated with streptokinase alone. The study of patients receiving heparin for deep vein thrombosis suggested that SPA may derive from adenosine diphosphate released from platelets during sample handling. We suggest that heparin infusion may facilitate ex vivo platelet activation and that this mechanism is operative in patients with acute myocardial infarction who have undergone thrombolytic therapy.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalPathophysiology of Haemostasis and Thrombosis
Volume23
Issue number4
DOIs
Publication statusPublished - 1993

Keywords

  • Acute myocardial infarction
  • Deep vein thrombosis
  • Heparin
  • Platelets
  • Spontaneous platelet aggregation

ASJC Scopus subject areas

  • Hematology
  • Physiology (medical)

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