Heparin, monocytes, and procoagulant activity

R. Abbate, A. M. Gori, P. A. Modesti, M. Attanasio, F. Martini, A. Colella, B. Giusti, I. Cecioni, G. G Neri Serneri

Research output: Contribution to journalArticlepeer-review

Abstract

Monocytes are able to specifically bind heparin rapidly, reversibly, and satura- bly with 5.5 ± 2.6 X 106 binding sites per monocyte and a dissociation constant of 330 ± 221 nmol/1. Moreover, at least 40-50% of the cell-bound heparin can be internalized. Heparin binding by monocytes is affected by cell stimulation with an increase of the availability of binding sites after challenge with calcium ionophore, lipopolysaccharide, and interleukin 2. The interaction of heparin with monocytes reversibly decreases the expression of tissue factor on the cellular surface, so hampering the cellular procoagulant potential.

Original languageEnglish
Pages (from-to)98-100
Number of pages3
JournalPathophysiology of Haemostasis and Thrombosis
Volume20
DOIs
Publication statusPublished - 1990

Keywords

  • Heparin
  • Monocytes
  • Tissue factor

ASJC Scopus subject areas

  • Hematology
  • Physiology (medical)

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