Heparin, monocytes, and procoagulant activity

R. Abbate; A. M. Gori; P. A. Modesti; M. Attanasio; F. Martini; A. Colella; B. Giusti; I. Cecioni; G. G Neri Serneri

doi:10.1159/000216166

Heparin, monocytes, and procoagulant activity

R. Abbate, A. M. Gori, P. A. Modesti, M. Attanasio, F. Martini, A. Colella, B. Giusti, I. Cecioni, G. G Neri Serneri

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Monocytes are able to specifically bind heparin rapidly, reversibly, and satura- bly with 5.5 ± 2.6 X 10⁶ binding sites per monocyte and a dissociation constant of 330 ± 221 nmol/1. Moreover, at least 40-50% of the cell-bound heparin can be internalized. Heparin binding by monocytes is affected by cell stimulation with an increase of the availability of binding sites after challenge with calcium ionophore, lipopolysaccharide, and interleukin 2. The interaction of heparin with monocytes reversibly decreases the expression of tissue factor on the cellular surface, so hampering the cellular procoagulant potential.

Original language	English
Pages (from-to)	98-100
Number of pages	3
Journal	Pathophysiology of Haemostasis and Thrombosis
Volume	20
DOIs	https://doi.org/10.1159/000216166
Publication status	Published - 1990

Keywords

Heparin
Monocytes
Tissue factor

ASJC Scopus subject areas

Hematology
Physiology (medical)

Access to Document

10.1159/000216166

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abstract = "Monocytes are able to specifically bind heparin rapidly, reversibly, and satura- bly with 5.5 ± 2.6 X 106 binding sites per monocyte and a dissociation constant of 330 ± 221 nmol/1. Moreover, at least 40-50% of the cell-bound heparin can be internalized. Heparin binding by monocytes is affected by cell stimulation with an increase of the availability of binding sites after challenge with calcium ionophore, lipopolysaccharide, and interleukin 2. The interaction of heparin with monocytes reversibly decreases the expression of tissue factor on the cellular surface, so hampering the cellular procoagulant potential.",

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AU - Abbate, R.

AU - Gori, A. M.

AU - Modesti, P. A.

AU - Attanasio, M.

AU - Martini, F.

AU - Colella, A.

AU - Giusti, B.

AU - Cecioni, I.

AU - Serneri, G. G Neri

PY - 1990

Y1 - 1990

N2 - Monocytes are able to specifically bind heparin rapidly, reversibly, and satura- bly with 5.5 ± 2.6 X 106 binding sites per monocyte and a dissociation constant of 330 ± 221 nmol/1. Moreover, at least 40-50% of the cell-bound heparin can be internalized. Heparin binding by monocytes is affected by cell stimulation with an increase of the availability of binding sites after challenge with calcium ionophore, lipopolysaccharide, and interleukin 2. The interaction of heparin with monocytes reversibly decreases the expression of tissue factor on the cellular surface, so hampering the cellular procoagulant potential.

AB - Monocytes are able to specifically bind heparin rapidly, reversibly, and satura- bly with 5.5 ± 2.6 X 106 binding sites per monocyte and a dissociation constant of 330 ± 221 nmol/1. Moreover, at least 40-50% of the cell-bound heparin can be internalized. Heparin binding by monocytes is affected by cell stimulation with an increase of the availability of binding sites after challenge with calcium ionophore, lipopolysaccharide, and interleukin 2. The interaction of heparin with monocytes reversibly decreases the expression of tissue factor on the cellular surface, so hampering the cellular procoagulant potential.

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KW - Monocytes

KW - Tissue factor

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