Heparin preserves antithrombin III biological activity from hyperglycemia-induced alterations in insulin-dependent diabetics

A. Ceriello, D. Giugliano, A. Quatraro, A. Stante, G. Consoli, P. Dello Russo, F. D'Onofrio

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Abstract

Alteration in antithrombin III (ATIII) biological activity, despite its normal plasma concentration, in diabetic subjects is shown in this report. This alteration is glycemia level-dependent, there existing an inverse correlation between fluctuations of daily blood glucose level, labile glycosylated hemoglobin and ATIII activity. The subcutaneous and endovenous heparin administration restores ATIII activity, but does not modify its plasma concentration in diabetics. Moreover, heparin treatment preserves ATIII activity from glycemia-induced alterations. These data suggest a role for glucose, probably through a labile nonenzymatic glycation process, in determining the alteration of ATIII biological activity. Moreover, showing the possibility by heparin administration to restore ATIII activity and preserve its biological function from effects of glycemia variations, stress the hypothesis that glucose and heparin compete in vivo, both against the same catalytic residue of ATIII.

Original languageEnglish
Pages (from-to)458-464
Number of pages7
JournalHaemostasis
Volume16
Issue number6
Publication statusPublished - 1986

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ASJC Scopus subject areas

  • Hematology

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Ceriello, A., Giugliano, D., Quatraro, A., Stante, A., Consoli, G., Dello Russo, P., & D'Onofrio, F. (1986). Heparin preserves antithrombin III biological activity from hyperglycemia-induced alterations in insulin-dependent diabetics. Haemostasis, 16(6), 458-464.