Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

Silvia Ghezzi; Lynsay Cooper; Alicia Rubio; Isabel Pagani; Maria Rosaria Capobianchi; Giuseppe Ippolito; Julien Pelletier; Maria Cecilia Z. Meneghetti; Marcelo A. Lima; Mark A. Skidmore; Vania Broccoli; Edwin A. Yates; Elisa Vicenzi

doi:10.1016/j.antiviral.2016.12.023

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

Silvia Ghezzi, Lynsay Cooper, Alicia Rubio, Isabel Pagani, Maria Rosaria Capobianchi, Giuseppe Ippolito, Julien Pelletier, Maria Cecilia Z. Meneghetti, Marcelo A. Lima, Mark A. Skidmore, Vania Broccoli, Edwin A. Yates, Elisa Vicenzi

Research output: Contribution to journal › Article › peer-review

Abstract

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs).

Original language	English
Pages (from-to)	13-17
Number of pages	5
Journal	Antiviral Research
Volume	140
DOIs	https://doi.org/10.1016/j.antiviral.2016.12.023
Publication status	Published - Apr 1 2017

Keywords

Cell death
Heparin
Neural progenitor cells
Zika virus (ZIKV)

ASJC Scopus subject areas

Pharmacology
Virology

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10.1016/j.antiviral.2016.12.023

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Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells. / Ghezzi, Silvia; Cooper, Lynsay; Rubio, Alicia; Pagani, Isabel; Capobianchi, Maria Rosaria ; Ippolito, Giuseppe; Pelletier, Julien; Meneghetti, Maria Cecilia Z.; Lima, Marcelo A.; Skidmore, Mark A.; Broccoli, Vania; Yates, Edwin A.; Vicenzi, Elisa.

In: Antiviral Research, Vol. 140, 01.04.2017, p. 13-17.

Research output: Contribution to journal › Article › peer-review

Ghezzi, Silvia ; Cooper, Lynsay ; Rubio, Alicia ; Pagani, Isabel ; Capobianchi, Maria Rosaria ; Ippolito, Giuseppe ; Pelletier, Julien ; Meneghetti, Maria Cecilia Z. ; Lima, Marcelo A. ; Skidmore, Mark A. ; Broccoli, Vania ; Yates, Edwin A. ; Vicenzi, Elisa. / Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells. In: Antiviral Research. 2017 ; Vol. 140. pp. 13-17.

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AU - Ippolito, Giuseppe

AU - Pelletier, Julien

AU - Meneghetti, Maria Cecilia Z.

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