Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

Silvia Ghezzi, Lynsay Cooper, Alicia Rubio, Isabel Pagani, Maria Rosaria Capobianchi, Giuseppe Ippolito, Julien Pelletier, Maria Cecilia Z. Meneghetti, Marcelo A. Lima, Mark A. Skidmore, Vania Broccoli, Edwin A. Yates, Elisa Vicenzi

Research output: Contribution to journalArticlepeer-review

Abstract

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs).

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalAntiviral Research
Volume140
DOIs
Publication statusPublished - Apr 1 2017

Keywords

  • Cell death
  • Heparin
  • Neural progenitor cells
  • Zika virus (ZIKV)

ASJC Scopus subject areas

  • Pharmacology
  • Virology

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