Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

S Ghezzi, L Cooper, Alicia Rubio, I Pagani, MR Capobianchi, G Ippolito, J Pelletier, MCZ Meneghetti, MA Lima, MA Skidmore, V Broccoli, EA Yates, E Vicenzi

Research output: Contribution to journalArticlepeer-review

Abstract

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs). © 2017 Elsevier B.V.
Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalAntiviral Research
Volume140
Issue number6
DOIs
Publication statusPublished - 2017

Fingerprint Dive into the research topics of 'Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells'. Together they form a unique fingerprint.

Cite this