Hepatic and extrahepatic formation and hydration of styrene oxide in vitro in animals of different species and sex

L. Cantoni, M. Salmona, T. Facchinetti, C. Pantarotto, G. Belvedere

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Styrene monooxygenase and epoxide hydratase activities were studied in the hepatic and extrahepatic microsomal fractions of male and female rats, mice, guinea pigs and rabbits. The highest specific acitivity of both enzymes was present in the liver where levels of epoxide hydratase were higher than monooxygenase. The two enzyme systems are present in all the tissues of both sexes of the species considered. A particularly high ratio of monoxygenase to hydratase activities was found in mouse and rabbit lungs.

Original languageEnglish
Pages (from-to)179-186
Number of pages8
JournalToxicology Letters
Volume2
Issue number3
DOIs
Publication statusPublished - 1978

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styrene oxide
Epoxide Hydrolases
Hydration
Animals
Hydro-Lyases
Rabbits
Liver
Enzymes
Mixed Function Oxygenases
Rats
Guinea Pigs
Tissue
Lung
In Vitro Techniques

ASJC Scopus subject areas

  • Toxicology

Cite this

Hepatic and extrahepatic formation and hydration of styrene oxide in vitro in animals of different species and sex. / Cantoni, L.; Salmona, M.; Facchinetti, T.; Pantarotto, C.; Belvedere, G.

In: Toxicology Letters, Vol. 2, No. 3, 1978, p. 179-186.

Research output: Contribution to journalArticle

Cantoni, L. ; Salmona, M. ; Facchinetti, T. ; Pantarotto, C. ; Belvedere, G. / Hepatic and extrahepatic formation and hydration of styrene oxide in vitro in animals of different species and sex. In: Toxicology Letters. 1978 ; Vol. 2, No. 3. pp. 179-186.
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