Hepatic colorectal cancer metastases showing a distinctive pattern of pathological response after metronomic capecitabine and bevacizumab

Filippo Pietrantonio, Pamela Biondani, Alessandro Pellegrinelli, Alfonso Marchianò, Katia Fiorella Dotti, Roberto Buzzoni, Maria Di Bartolomeo

Research output: Contribution to journalArticlepeer-review

Abstract

A 48-year-old man was referred to our hospital with the diagnosis of colon cancer with multiple hepatic metastases. After right hemicolectomy, the rapid progression of liver disease was treated with metronomic capecitabine and bevacizumab according to a study protocol. A gradual regression of metastatic lesions was observed during a 9-month treatment period. After conversion of liver disease to resectability, the histological examination disclosed the complete necrosis of all lesions, with the exception of small neoplastic foci inside a single nodule. The comparison of this type of histological findings with the classic sclero-hyaline pathological response, as well as its importance as indicator of response to antiangiogenic treatment, is discussed.

Original languageEnglish
Pages (from-to)2838-2841
Number of pages4
JournalMedical Oncology
Volume29
Issue number4
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Bevacizumab
  • Colorectal cancer
  • Liver metastases
  • Metronomic chemotherapy
  • Pathological complete response

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Hematology

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