Hepatic function and fibrinolysis in patients with hereditary angioedema undergoing long-term treatment with tranexamic acid

A. Agostoni, B. Marasini, M. Cicardi, G. Martignoni, L. Uziel, M. Pietrogrande

Research output: Contribution to journalArticle

Abstract

Prophylactic treatment with antifibrinolytic agents, epsilon-aminocaproic and tranexamic acid, reduces the incidence and severity of attacks in patients with hereditary angioedema. Long-term effectiveness or risk of antifibrinolytic agents has not been established. Sixteen patients needing continuous prophylaxis because of frequency and severity of attacks were traced with tranexamic acid. In four patients this treatment was ineffective and the drug was withdrawn after 2 months. A remission or reduction in the frequency or severity of attacks was observed in 12 patients treated for a period ranging from 8 to 34 months. Hepatic tests and blood fibrinolytic activity were not influenced by long-term oral treatment with tranexamic acid.

Original languageEnglish
Pages (from-to)216-221
Number of pages6
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume33
Issue number4
Publication statusPublished - 1978

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ASJC Scopus subject areas

  • Immunology

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