Hepatic intra-arterial chemotherapy (HIAC) of high dose mitomycin and epirubicin combined with caval chemofiltration versus prolonged low doses in liver metastases from colorectal cancer: A prospective randomized clinical study

Giammaria Fiorentini; D. B. Poddie; M. Cantore; S. Rossi; S. Tumolo; P. Dentico; P. Bernardeschi; S. Guadagni; G. Rossi; V. M. Valori; M. De Simone

Hepatic intra-arterial chemotherapy (HIAC) of high dose mitomycin and epirubicin combined with caval chemofiltration versus prolonged low doses in liver metastases from colorectal cancer: A prospective randomized clinical study

Giammaria Fiorentini, D. B. Poddie, M. Cantore, S. Rossi, S. Tumolo, P. Dentico, P. Bernardeschi, S. Guadagni, G. Rossi, V. M. Valori, M. De Simone

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Abstract

A multicenter randomized study comparing high dose of mitomycin and epirubicin given as hepatic intra-arterial chemotherapy (HIAC) combined with caval chemofiltration (CF) versus low doses of the same drugs in unresectable liver metastases from colorectal cancer showed a significant improvement in the survival rate of the 20 patients treated with high dose compared to the 22 patients treated with low doses with a 1 year survival of 69% vs 39%. The median survival was 17 vs 11 months and the responses were 65% vs 33%. Toxicity was colangitis in 50% of patients considered. The extrahepatic progression was similar in the two groups (7/20 vs 8/22).

Original language	English
Pages (from-to)	51-54
Number of pages	4
Journal	Journal of Chemotherapy
Volume	16
Issue number	SUPPL. 5
Publication status	Published - Nov 2004

Keywords

Chemofiltration
Intra-arterial chemotherapy
Liver metastases

ASJC Scopus subject areas

Pharmacology (medical)
Microbiology (medical)

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Fiorentini, G., Poddie, D. B., Cantore, M., Rossi, S., Tumolo, S., Dentico, P., Bernardeschi, P., Guadagni, S., Rossi, G., Valori, V. M., & De Simone, M. (2004). Hepatic intra-arterial chemotherapy (HIAC) of high dose mitomycin and epirubicin combined with caval chemofiltration versus prolonged low doses in liver metastases from colorectal cancer: A prospective randomized clinical study. Journal of Chemotherapy, 16(SUPPL. 5), 51-54.

Hepatic intra-arterial chemotherapy (HIAC) of high dose mitomycin and epirubicin combined with caval chemofiltration versus prolonged low doses in liver metastases from colorectal cancer : A prospective randomized clinical study. / Fiorentini, Giammaria; Poddie, D. B.; Cantore, M.; Rossi, S.; Tumolo, S.; Dentico, P.; Bernardeschi, P.; Guadagni, S.; Rossi, G.; Valori, V. M.; De Simone, M.

In: Journal of Chemotherapy, Vol. 16, No. SUPPL. 5, 11.2004, p. 51-54.

Research output: Contribution to journal › Article › peer-review

Fiorentini, G, Poddie, DB, Cantore, M, Rossi, S, Tumolo, S, Dentico, P, Bernardeschi, P, Guadagni, S, Rossi, G, Valori, VM & De Simone, M 2004, 'Hepatic intra-arterial chemotherapy (HIAC) of high dose mitomycin and epirubicin combined with caval chemofiltration versus prolonged low doses in liver metastases from colorectal cancer: A prospective randomized clinical study', Journal of Chemotherapy, vol. 16, no. SUPPL. 5, pp. 51-54.

Fiorentini, Giammaria ; Poddie, D. B. ; Cantore, M. ; Rossi, S. ; Tumolo, S. ; Dentico, P. ; Bernardeschi, P. ; Guadagni, S. ; Rossi, G. ; Valori, V. M. ; De Simone, M. / Hepatic intra-arterial chemotherapy (HIAC) of high dose mitomycin and epirubicin combined with caval chemofiltration versus prolonged low doses in liver metastases from colorectal cancer : A prospective randomized clinical study. In: Journal of Chemotherapy. 2004 ; Vol. 16, No. SUPPL. 5. pp. 51-54.

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abstract = "A multicenter randomized study comparing high dose of mitomycin and epirubicin given as hepatic intra-arterial chemotherapy (HIAC) combined with caval chemofiltration (CF) versus low doses of the same drugs in unresectable liver metastases from colorectal cancer showed a significant improvement in the survival rate of the 20 patients treated with high dose compared to the 22 patients treated with low doses with a 1 year survival of 69% vs 39%. The median survival was 17 vs 11 months and the responses were 65% vs 33%. Toxicity was colangitis in 50% of patients considered. The extrahepatic progression was similar in the two groups (7/20 vs 8/22).",

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