Abstract
A multicenter randomized study comparing high dose of mitomycin and epirubicin given as hepatic intra-arterial chemotherapy (HIAC) combined with caval chemofiltration (CF) versus low doses of the same drugs in unresectable liver metastases from colorectal cancer showed a significant improvement in the survival rate of the 20 patients treated with high dose compared to the 22 patients treated with low doses with a 1 year survival of 69% vs 39%. The median survival was 17 vs 11 months and the responses were 65% vs 33%. Toxicity was colangitis in 50% of patients considered. The extrahepatic progression was similar in the two groups (7/20 vs 8/22).
Original language | English |
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Pages (from-to) | 51-54 |
Number of pages | 4 |
Journal | Journal of Chemotherapy |
Volume | 16 |
Issue number | SUPPL. 5 |
Publication status | Published - Nov 2004 |
Keywords
- Chemofiltration
- Intra-arterial chemotherapy
- Liver metastases
ASJC Scopus subject areas
- Pharmacology (medical)
- Microbiology (medical)