Hepatic intra-arterial chemotherapy (HIAC) of high dose mitomycin and epirubicin combined with caval chemofiltration versus prolonged low doses in liver metastases from colorectal cancer

A prospective randomized clinical study

Giammaria Fiorentini, D. B. Poddie, M. Cantore, S. Rossi, S. Tumolo, P. Dentico, P. Bernardeschi, S. Guadagni, G. Rossi, V. M. Valori, M. De Simone

Research output: Contribution to journalArticle

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Abstract

A multicenter randomized study comparing high dose of mitomycin and epirubicin given as hepatic intra-arterial chemotherapy (HIAC) combined with caval chemofiltration (CF) versus low doses of the same drugs in unresectable liver metastases from colorectal cancer showed a significant improvement in the survival rate of the 20 patients treated with high dose compared to the 22 patients treated with low doses with a 1 year survival of 69% vs 39%. The median survival was 17 vs 11 months and the responses were 65% vs 33%. Toxicity was colangitis in 50% of patients considered. The extrahepatic progression was similar in the two groups (7/20 vs 8/22).

Original languageEnglish
Pages (from-to)51-54
Number of pages4
JournalJournal of Chemotherapy
Volume16
Issue numberSUPPL. 5
Publication statusPublished - Nov 2004

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Epirubicin
Venae Cavae
Mitomycin
Colorectal Neoplasms
Neoplasm Metastasis
Drug Therapy
Liver
Survival
Multicenter Studies
Survival Rate
Pharmaceutical Preparations
Clinical Studies

Keywords

  • Chemofiltration
  • Intra-arterial chemotherapy
  • Liver metastases

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Microbiology (medical)

Cite this

Hepatic intra-arterial chemotherapy (HIAC) of high dose mitomycin and epirubicin combined with caval chemofiltration versus prolonged low doses in liver metastases from colorectal cancer : A prospective randomized clinical study. / Fiorentini, Giammaria; Poddie, D. B.; Cantore, M.; Rossi, S.; Tumolo, S.; Dentico, P.; Bernardeschi, P.; Guadagni, S.; Rossi, G.; Valori, V. M.; De Simone, M.

In: Journal of Chemotherapy, Vol. 16, No. SUPPL. 5, 11.2004, p. 51-54.

Research output: Contribution to journalArticle

Fiorentini, Giammaria ; Poddie, D. B. ; Cantore, M. ; Rossi, S. ; Tumolo, S. ; Dentico, P. ; Bernardeschi, P. ; Guadagni, S. ; Rossi, G. ; Valori, V. M. ; De Simone, M. / Hepatic intra-arterial chemotherapy (HIAC) of high dose mitomycin and epirubicin combined with caval chemofiltration versus prolonged low doses in liver metastases from colorectal cancer : A prospective randomized clinical study. In: Journal of Chemotherapy. 2004 ; Vol. 16, No. SUPPL. 5. pp. 51-54.
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abstract = "A multicenter randomized study comparing high dose of mitomycin and epirubicin given as hepatic intra-arterial chemotherapy (HIAC) combined with caval chemofiltration (CF) versus low doses of the same drugs in unresectable liver metastases from colorectal cancer showed a significant improvement in the survival rate of the 20 patients treated with high dose compared to the 22 patients treated with low doses with a 1 year survival of 69{\%} vs 39{\%}. The median survival was 17 vs 11 months and the responses were 65{\%} vs 33{\%}. Toxicity was colangitis in 50{\%} of patients considered. The extrahepatic progression was similar in the two groups (7/20 vs 8/22).",
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