Hepatic iron overload in patients with chronic viral hepatitis

Role of HFE gene mutations

Alberto Piperno, Anna Vergani, Ida Malosio, Laura Parma, Laura Fossati, Alessandra Ricci, Giorgio Bovo, Giuseppe Boari, Giuseppe Mancia

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Mild to moderate hepatic iron overload is frequent in patients with chronic viral hepatitis (CH). We evaluated the role of hemochromatosis (HFE) gene mutations and other acquired factors in the development of iron overload in these patients. We studied 110 patients with chronic B or C viral hepatitis (31 women, 79 men), including 20 with cirrhosis, and 139 controls. Hepatic iron was evaluated by semiquantitative analysis in all the patients, and hepatic iron concentration (HIC) was determined in 97 of them (26 women, 71 men). C282Y and H63D mutations were sought in all the subjects by a polymerase chain reaction-restriction assay. The frequency of HFE genotypes and alleles did not differ in patients and controls. No relation was detected between hepatic iron stores and HFE gene mutations in women. In men, all C282Y heterozygotes had iron overload, and the H63D mutation was significantly more frequent in patients with more marked hepatic siderosis than in those with mild or no siderosis (P = .0039) and in controls (P = .0008). Heavy alcohol intake and hepatic cirrhosis were also associated with increased hepatic iron stores in the men. In the 71 men in whom HIC was measured, multiple regression analysis showed that this variable was related independently only to alcohol intake and HFE gene mutations. We suggest that in patients with CH, iron accumulates in the liver as the result of an interplay between genetic and acquired factors, and that increased liver iron stores may influence progression toward liver fibrosis.

Original languageEnglish
Pages (from-to)1105-1109
Number of pages5
JournalHepatology
Volume28
Issue number4 I
DOIs
Publication statusPublished - 1998

Fingerprint

Iron Overload
Chronic Hepatitis
Mutation
Iron
Liver
Genes
Siderosis
Liver Cirrhosis
Alcohols
Hemochromatosis
Heterozygote
Hepatitis C
Fibrosis
Alleles
Genotype
Regression Analysis
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Hepatology

Cite this

Piperno, A., Vergani, A., Malosio, I., Parma, L., Fossati, L., Ricci, A., ... Mancia, G. (1998). Hepatic iron overload in patients with chronic viral hepatitis: Role of HFE gene mutations. Hepatology, 28(4 I), 1105-1109. https://doi.org/10.1002/hep.510280427

Hepatic iron overload in patients with chronic viral hepatitis : Role of HFE gene mutations. / Piperno, Alberto; Vergani, Anna; Malosio, Ida; Parma, Laura; Fossati, Laura; Ricci, Alessandra; Bovo, Giorgio; Boari, Giuseppe; Mancia, Giuseppe.

In: Hepatology, Vol. 28, No. 4 I, 1998, p. 1105-1109.

Research output: Contribution to journalArticle

Piperno, A, Vergani, A, Malosio, I, Parma, L, Fossati, L, Ricci, A, Bovo, G, Boari, G & Mancia, G 1998, 'Hepatic iron overload in patients with chronic viral hepatitis: Role of HFE gene mutations', Hepatology, vol. 28, no. 4 I, pp. 1105-1109. https://doi.org/10.1002/hep.510280427
Piperno A, Vergani A, Malosio I, Parma L, Fossati L, Ricci A et al. Hepatic iron overload in patients with chronic viral hepatitis: Role of HFE gene mutations. Hepatology. 1998;28(4 I):1105-1109. https://doi.org/10.1002/hep.510280427
Piperno, Alberto ; Vergani, Anna ; Malosio, Ida ; Parma, Laura ; Fossati, Laura ; Ricci, Alessandra ; Bovo, Giorgio ; Boari, Giuseppe ; Mancia, Giuseppe. / Hepatic iron overload in patients with chronic viral hepatitis : Role of HFE gene mutations. In: Hepatology. 1998 ; Vol. 28, No. 4 I. pp. 1105-1109.
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