Hepatic metastases of colorectal cancer

Locoregional intra-arterial treatment

Lara Maria Pasetto, Roberto Merenda, Pierluigi Pilati, Giulietta Sinigaglia, Silvio Monfardini

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A radical resection alone of colorectal hepatic metastases is possible in only 10-20% of the patients but, when resection and ablation are combined, the rate of radicalism can improve. A regional hepatic intra-arterial chemotherapy infusion (HAI) has been introduced in the clinical practice, as a possible alternative approach to systemic chemotherapy. Nevertheless, the introduction of new systemic therapies with monoclonal antibodies, combined to irinotecan or oxaliplatin, recently improved response rates and overall survival in these patients. Aiming to evaluate a possible influence of HAI in these new treatments, the most important studies underlining the evolution of intrahepatic administration in recent years are reviewed.

Original languageEnglish
Pages (from-to)4785-4792
Number of pages8
JournalAnticancer Research
Volume26
Issue number6 C
Publication statusPublished - Nov 2006

Fingerprint

oxaliplatin
irinotecan
Colorectal Neoplasms
Neoplasm Metastasis
Drug Therapy
Intra Arterial Infusions
Liver
Survival Rate
Monoclonal Antibodies
Therapeutics

Keywords

  • Colorectal cancer
  • Intra-arterial chemotherapy
  • Liver metastases
  • Review

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pasetto, L. M., Merenda, R., Pilati, P., Sinigaglia, G., & Monfardini, S. (2006). Hepatic metastases of colorectal cancer: Locoregional intra-arterial treatment. Anticancer Research, 26(6 C), 4785-4792.

Hepatic metastases of colorectal cancer : Locoregional intra-arterial treatment. / Pasetto, Lara Maria; Merenda, Roberto; Pilati, Pierluigi; Sinigaglia, Giulietta; Monfardini, Silvio.

In: Anticancer Research, Vol. 26, No. 6 C, 11.2006, p. 4785-4792.

Research output: Contribution to journalArticle

Pasetto, LM, Merenda, R, Pilati, P, Sinigaglia, G & Monfardini, S 2006, 'Hepatic metastases of colorectal cancer: Locoregional intra-arterial treatment', Anticancer Research, vol. 26, no. 6 C, pp. 4785-4792.
Pasetto LM, Merenda R, Pilati P, Sinigaglia G, Monfardini S. Hepatic metastases of colorectal cancer: Locoregional intra-arterial treatment. Anticancer Research. 2006 Nov;26(6 C):4785-4792.
Pasetto, Lara Maria ; Merenda, Roberto ; Pilati, Pierluigi ; Sinigaglia, Giulietta ; Monfardini, Silvio. / Hepatic metastases of colorectal cancer : Locoregional intra-arterial treatment. In: Anticancer Research. 2006 ; Vol. 26, No. 6 C. pp. 4785-4792.
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