Hepatic metastases: Percutaneous radio-frequency ablation with cooled- tip electrodes

Luigi Solbiati, S. Nahum Goldberg, Tiziana Ierace, Tito Livraghi, Franca Meloni, Marina Dellanoce, Sandro Sironi, G. Scott Gazelle

Research output: Contribution to journalArticlepeer-review


PURPOSE: To assess the feasibility and safety of using cooled-tip electrodes to increase the volume of coagulation necrosis obtained or reduce the number of treatment sessions necessary with percutaneous tumor radio- frequency (RF) ablation. MATERIALS AND METHODS: Twenty-nine patients with 44 hepatic metastases (1.3-5.1 cm diameter) from colorectal (n = 22), gastric (n = 5), pancreatic (n = 1), or breast (n = 1) carcinoma were treated with RF ablation using cooled-tip, 18-gauge electrodes with 2-3 cm tip exposure. Each tumor was treated in one or two treatment sessions. RESULTS: Technical success, ablation of all visualized tumor, was achieved in 40 (91%) metastases. Findings at computed tomography (CT) and magnetic resonance (MR) imaging performed 3-6 months after treatment confirmed complete necrosis of the entire metastasis in 66%. Disease-free survival was 50% at 12 months and 33% at 18 months, with localized progression of disease in 34% of treated lesions. Overall survival was 100%, 94%, and 89% at 6, 12, and 18 months, respectively. Only one complication, self-limited hemorrhage, was seen. CONCLUSION: Use of cooled-tip electrodes was a safe and feasible adjunct for tumor RF ablation therapy that produced larger volumes of coagulation necrosis with fewer electrode insertions than is produced with other RF ablation techniques.

Original languageEnglish
Pages (from-to)367-373
Number of pages7
Issue number2
Publication statusPublished - Nov 1997


  • Liver neoplasms, secondary
  • Liver neoplasms, therapy
  • Radiofrequency (RF) ablation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology


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