Hepatic steatosis is uncommon in children with chronic hepatitis B

Antonietta Giannattasio, Francesco Cirillo, Vito Terlizzi, Daniela Liccardo, Raffaella Vecchione, Raffaele Iorio

Research output: Contribution to journalArticle

Abstract

Background: Differently from chronic hepatitis C, factors associated with hepatic steatosis in children with chronic hepatitis B are not clearly elucidated. Objective: Aim of this study was to investigate prevalence of steatosis at liver biopsy in HBV-infected children. Study design: A retrospective study including 56 children with chronic hepatitis B undergoing liver biopsy at median age of 8.1 years. In all patients demographic, anthropometric, clinical and laboratory data were evaluated at the time of liver biopsy. Results: Steatosis was present in 2 (4%) children. BMI was significantly higher in 2 patients with steatosis compared with those without steatosis. Demographic, biochemical and virological parameters did not differ between children with and those without steatosis. Conclusions: Liver steatosis in HBV-infected children seems to be related to obesity and metabolic factors rather than to viral factors. Detection of steatosis in non-obese children with HBV infection requires a careful investigation to rule out other causes of fatty liver.

Original languageEnglish
Pages (from-to)360-362
Number of pages3
JournalJournal of Clinical Virology
Volume46
Issue number4
DOIs
Publication statusPublished - Dec 2009

Keywords

  • Children
  • HBV
  • Liver steatosis

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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    Giannattasio, A., Cirillo, F., Terlizzi, V., Liccardo, D., Vecchione, R., & Iorio, R. (2009). Hepatic steatosis is uncommon in children with chronic hepatitis B. Journal of Clinical Virology, 46(4), 360-362. https://doi.org/10.1016/j.jcv.2009.09.021