The hepatocyte is traditionally considered as the cell responsible for liver regeneration, being able to enter in cell cycle and to restore hepatic parenchyma. However, a stem cell compartment (so called "oval cells") is activated in response to injury when the proliferative capacity of the hepatocyte is altered. Recent studies suggest that at least a subpopulation of oval cells may originate from bone marrow-derived stem cells. Such observations can have an important impact both on theories concerning cell differentiation and on cell therapy in liver disease.
|Translated title of the contribution||Hepatic stem cells|
|Number of pages||9|
|Journal||Argomenti di Gastroenterologia Clinica|
|Publication status||Published - Mar 2004|
ASJC Scopus subject areas