Hepatic tumor and tumor-like lesions in childhood

F. Callea, M. Bonetti, D. Medicina, D. Alberti, G. Fabbretti, M. Brisigotti

Research output: Contribution to journalArticlepeer-review


Tumors of the liver are rare in infancy and childhood. Some are peculiar to the pediatric age, e.g., hepatoblastoma, infantile hemangioendothelioma, mesenchymal hamartoma, embryonal rhabdomyosarcoma. This review is based upon personal experience with a series of 32 cases. On the basis of the histological features it is proposed that focal modular hyperplasia (FNH) and mesenchymal hamartoma be considered as tumor-like lesions rather than true neoplasms. A few benign epithelial lesions (FNH, adenoma) were associated with inborn error of metabolism. In half of the patients, hepatocellular carcinoma (HCC) developed in perinatally hepatitis B virus (HBV)-infected children. HCC developed in a noncirrhotic liver in a single patient, in whom HBV-DNA integration had occurred.

Original languageEnglish
Pages (from-to)170-172
Number of pages3
JournalJournal of Surgical Oncology
Issue numberSUPPL. 3
Publication statusPublished - 1993


  • childhood
  • liver
  • tumor
  • tumor-like lesions

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Surgery


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