Hepatic tumor and tumor‐like lesions in childhood

Francesco Callea, Mariafausta Bonetti, Daniela Medicina, Daniele Alberti, Giovanna Fabbretti, Massimo Brisigotti

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Tumors of the liver are rare in infancy and childhood. Some are peculiar to the pediatric age, e.g., hepatoblastoma, infantile hemangioendothelioma, mesenchymal hamartoma, embryonal rhabdomyosarcoma. This review is based upon personal experience with a series of 32 cases. On the basis of the histological features it is proposed that focal modular hyperplasia (FNH) and mesenchymal hamartoma be considered as tumor‐like lesions rather than true neoplasms. A few benign epithelial lesions (FNH, adenoma) were associated with inborn error of metabolism. In half of the patients, hepatocellular carcinoma (HCC) developed in perinatally hepatitis B virus (HBV)‐infected children. HCC developed in a noncirrhotic liver in a single patient, in whom HB V‐DNA integration had occurred. © 1993 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)170-172
Number of pages3
JournalJournal of Surgical Oncology
Issue number3 S
Publication statusPublished - 1993


  • childhood
  • liver
  • tumor
  • tumor‐like lesions

ASJC Scopus subject areas

  • Surgery
  • Oncology


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