"Hepatitic flare", asthenia, peripheral polyneuropathy and diffuse liver steatosis in a hepatitis C virus asymptomatic chronic carrier

F. Caprioli, R. Pometta, S. Visentin, S. Massironi, D. Conte

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In July 2000, a 62-year-old female, with a ten-year history of chronic hepatitis C virus infection and persistently normal aspartate amino-transferase and alanine aminotransferase levels, presented with asthenia, weight loss, peripheral polyneuropathy and increased levels of aspartate aminotransferase (8 times upper normal limit), alanine aminotransferase (10 times upper normal limit) and gamma glutamyltransferase (6 times upper normal limit). The ultrasound findings were consistent with massive liver steatosis. The patient had been previously diagnosed elsewhere as having hepatitis C virus-related "hepatitic flare" with neurological involvement related to concomitant mixed type-III cryoglobulinaemia. However, intense exposure to trichloroethylene since April 2000 was revealed and liver histology was fully consistent with non-alcoholic steatohepatitis. The pathogenetic role of the solvent was definitely supported by the complete clinical and biochemical remission within six months of trichloroethylene withdrawal.

Original languageEnglish
Pages (from-to)359-362
Number of pages4
JournalDigestive and Liver Disease
Volume33
Issue number4
Publication statusPublished - 2001

Fingerprint

Trichloroethylene
Asthenia
Polyneuropathies
Fatty Liver
Alanine Transaminase
Hepacivirus
Cryoglobulinemia
gamma-Glutamyltransferase
Chronic Hepatitis C
Virus Diseases
Transferases
Aspartate Aminotransferases
Aspartic Acid
Weight Loss
Histology
Liver

Keywords

  • Cryoglobulins
  • Hepatitis C virus
  • Non-alcoholic steato-hepatitis
  • Trichloroethylene

ASJC Scopus subject areas

  • Gastroenterology

Cite this

"Hepatitic flare", asthenia, peripheral polyneuropathy and diffuse liver steatosis in a hepatitis C virus asymptomatic chronic carrier. / Caprioli, F.; Pometta, R.; Visentin, S.; Massironi, S.; Conte, D.

In: Digestive and Liver Disease, Vol. 33, No. 4, 2001, p. 359-362.

Research output: Contribution to journalArticle

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AU - Conte, D.

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