Abstract
Background: Hepatitis C virus (HCV) has been consistently associated to non-Hodgkin lymphoma (NHL); conversely, few studies have evaluated a comprehensive serological panel of hepatitis B virus (HBV) in NHL etiology. Methods: We conducted a case-control study in Italy in 1999-2014, enrolling 571 incident, histologically confirmed NHLs and 1004 cancer-free matched controls. Study subjects provided serum for HCV and HBV testing and for HCV RNA. Odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were estimated by logistic regression, adjusting for potential confounders. Results: Circulating HCV RNA was detected in 63 (11.1 %) NHL cases and 35 (3.5 %) controls (OR = 3.51, 95 % CI: 2.25-5.47). Chronic HBV infection (i.e., positive to HBV surface antigen - HBsAg+) was found in 3.7 % of cases and 1.7 % of controls (OR = 1.95, 95 % CI: 1.00-3.81); a significantly elevated OR was observed for B-cell NHL (2.11, 95 % CI: 1.07-4.15). People with serological evidence of past HCV or HBV infection, vaccination against HBV, or detectable antibodies against HBV core antigen (anti-HBc+) alone were not at increased NHL risk. Conclusions: Our results support a role of chronic HCV infection in NHL in Italy and suggest an involvement of HBV infection. Associations were clearest for B-cell NHL and diffuse large B-cell lymphoma. Prevention and treatment of HCV and HBV infection may diminish NHL incidence, notably in areas with high prevalence of hepatitis viruses infection.
| Original language | English |
|---|---|
| Article number | 27 |
| Journal | Infectious Agents and Cancer |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jun 23 2016 |
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Keywords
- Case-control study
- Hepatitis B virus
- Hepatitis C virus
- Non-Hodgkin lymphoma
ASJC Scopus subject areas
- Infectious Diseases
- Oncology
- Epidemiology
- Cancer Research
Cite this
Hepatitis B and C viruses and risk of non-Hodgkin lymphoma : A case-control study in Italy. / Taborelli, Martina; Polesel, Jerry; Montella, Maurizio; Libra, Massimo; Tedeschi, Rosamaria; Battiston, Monica; Spina, Michele; Di Raimondo, Francesco; Pinto, Antonio; Crispo, Anna; Grimaldi, Maria; Franceschi, Silvia; Dal Maso, Luigino; Serraino, Diego.
In: Infectious Agents and Cancer, Vol. 11, No. 1, 27, 23.06.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hepatitis B and C viruses and risk of non-Hodgkin lymphoma
T2 - A case-control study in Italy
AU - Taborelli, Martina
AU - Polesel, Jerry
AU - Montella, Maurizio
AU - Libra, Massimo
AU - Tedeschi, Rosamaria
AU - Battiston, Monica
AU - Spina, Michele
AU - Di Raimondo, Francesco
AU - Pinto, Antonio
AU - Crispo, Anna
AU - Grimaldi, Maria
AU - Franceschi, Silvia
AU - Dal Maso, Luigino
AU - Serraino, Diego
PY - 2016/6/23
Y1 - 2016/6/23
N2 - Background: Hepatitis C virus (HCV) has been consistently associated to non-Hodgkin lymphoma (NHL); conversely, few studies have evaluated a comprehensive serological panel of hepatitis B virus (HBV) in NHL etiology. Methods: We conducted a case-control study in Italy in 1999-2014, enrolling 571 incident, histologically confirmed NHLs and 1004 cancer-free matched controls. Study subjects provided serum for HCV and HBV testing and for HCV RNA. Odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were estimated by logistic regression, adjusting for potential confounders. Results: Circulating HCV RNA was detected in 63 (11.1 %) NHL cases and 35 (3.5 %) controls (OR = 3.51, 95 % CI: 2.25-5.47). Chronic HBV infection (i.e., positive to HBV surface antigen - HBsAg+) was found in 3.7 % of cases and 1.7 % of controls (OR = 1.95, 95 % CI: 1.00-3.81); a significantly elevated OR was observed for B-cell NHL (2.11, 95 % CI: 1.07-4.15). People with serological evidence of past HCV or HBV infection, vaccination against HBV, or detectable antibodies against HBV core antigen (anti-HBc+) alone were not at increased NHL risk. Conclusions: Our results support a role of chronic HCV infection in NHL in Italy and suggest an involvement of HBV infection. Associations were clearest for B-cell NHL and diffuse large B-cell lymphoma. Prevention and treatment of HCV and HBV infection may diminish NHL incidence, notably in areas with high prevalence of hepatitis viruses infection.
AB - Background: Hepatitis C virus (HCV) has been consistently associated to non-Hodgkin lymphoma (NHL); conversely, few studies have evaluated a comprehensive serological panel of hepatitis B virus (HBV) in NHL etiology. Methods: We conducted a case-control study in Italy in 1999-2014, enrolling 571 incident, histologically confirmed NHLs and 1004 cancer-free matched controls. Study subjects provided serum for HCV and HBV testing and for HCV RNA. Odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were estimated by logistic regression, adjusting for potential confounders. Results: Circulating HCV RNA was detected in 63 (11.1 %) NHL cases and 35 (3.5 %) controls (OR = 3.51, 95 % CI: 2.25-5.47). Chronic HBV infection (i.e., positive to HBV surface antigen - HBsAg+) was found in 3.7 % of cases and 1.7 % of controls (OR = 1.95, 95 % CI: 1.00-3.81); a significantly elevated OR was observed for B-cell NHL (2.11, 95 % CI: 1.07-4.15). People with serological evidence of past HCV or HBV infection, vaccination against HBV, or detectable antibodies against HBV core antigen (anti-HBc+) alone were not at increased NHL risk. Conclusions: Our results support a role of chronic HCV infection in NHL in Italy and suggest an involvement of HBV infection. Associations were clearest for B-cell NHL and diffuse large B-cell lymphoma. Prevention and treatment of HCV and HBV infection may diminish NHL incidence, notably in areas with high prevalence of hepatitis viruses infection.
KW - Case-control study
KW - Hepatitis B virus
KW - Hepatitis C virus
KW - Non-Hodgkin lymphoma
UR - http://www.scopus.com/inward/record.url?scp=84978245787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978245787&partnerID=8YFLogxK
U2 - 10.1186/s13027-016-0073-x
DO - 10.1186/s13027-016-0073-x
M3 - Article
AN - SCOPUS:84978245787
VL - 11
JO - Infectious Agents and Cancer
JF - Infectious Agents and Cancer
SN - 1750-9378
IS - 1
M1 - 27
ER -