Hepatitis B reactivation in HBsAg-negative/HBcAb-positive allogeneic haematopoietic stem cell transplant recipients: Risk factors and outcome

M. Mikulska, L. Nicolini, A. Signori, G. Rivoli, V. Del Bono, A. M. Raiola, C. Di Grazia, A. Dominietto, R. Varaldo, A. Ghiso, A. Bacigalupo, C. Viscoli

Research output: Contribution to journalArticlepeer-review

Abstract

HBsAg-negative/HBcAb-positive haematopoietic stem cell transplant (HSCT) recipients are at high risk of hepatitis B virus (HBV) reactivation. Allogeneic HSCT recipients from years 2000 to 2010 were evaluated in order to study the impact of being HBsAg-negative/HBcAb-positive in this population. Overall, 137 of 764 patients (18%) were HBsAg-negative/HBcAb-positive before HSCT. Overall survival, non-relapse mortality (NRM), acute and chronic graft-vs.-host disease were similar in HBcAb-positive and HBcAb-negative patients. Reactivation occurred in 14 patients (10%) within a median of 19 months after HSCT (range 9-77). Cause-specific hazard for reactivation was decreased in the case of an HBV-immune/exposed donor (HRadjusted = 0.12; 95% CI, 0.02-0.96; p 0.045) and increased in patients who received rituximab treatment (HRadjusted = 2.91; 95%CI, 0.77-10.97; p 0.11). Competing risk analyses documented a protective role of an HBV-immune/exposed donor (p 0.041) and an increased probability associated with the length of treatment with cyclosporine (p

Original languageEnglish
Pages (from-to)O694-O701
JournalClinical Microbiology and Infection
Volume20
Issue number10
DOIs
Publication statusPublished - Oct 1 2014

Keywords

  • Bone marrow transplant
  • Chronic graft-vs.-host disease
  • Cyclosporin
  • Occult HBV
  • Resolved HBV hepatitis
  • Reverse seroconversion
  • Rituximab

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

Fingerprint Dive into the research topics of 'Hepatitis B reactivation in HBsAg-negative/HBcAb-positive allogeneic haematopoietic stem cell transplant recipients: Risk factors and outcome'. Together they form a unique fingerprint.

Cite this