Hepatitis B vaccination failure in children with diabetes mellitus? The debate continues.

Salvatore Leonardi, Giovanna Vitaliti, Maria Teresa Garozzo, Michele Miraglia del Giudice, Gianluigi Marseglia, Mario La Rosa

Research output: Contribution to journalArticle

Abstract

The aim of our study was to evaluate the presence of specific antibodies against HBsAg in diabetic children (IDDM) previously vaccinated against hepatitis B virus. 110 diabetic children were retrospectively studied and 100 healthy controls were recruited. In all patients surface antigen, HBV core IgG, antibodies against HBV "e" antigen and quantitative HBV surface antibodies were detected. In 45 patients molecular typing of HLA alleles was performed. Metabolic control was evaluated as mean glycated hemoglobin (HbA1c) and all patients were compliant to insulin therapy. 46 of 110 diabetic children (41.8%) and 16 of 100 healthy controls (16%) were found to have not anti-HBs antibodies (p <0.0001). The mean antibody titer was found significantly-lower (p <0.0001) in IDDM children than healthy controls. No correlation was found between antibody titer, age, duration of disease and HbA1c. We did not find any difference of gender, age, years of onset of the disease and metabolic control, between diabetics with anti-HBs antibodies and those without. Our data confirm the reduced seroprotection rate for HBV vaccination in diabetics. However it remains poorly clarify the real clinical significance of this result. In our study no diabetic children showed markers of HBV infection.

Original languageEnglish
Pages (from-to)448-452
Number of pages5
JournalHuman Vaccines and Immunotherapeutics
Volume8
Issue number4
Publication statusPublished - Apr 2012

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Hepatitis B
Diabetes Mellitus
Vaccination
Antibodies
Type 1 Diabetes Mellitus
Anti-Idiotypic Antibodies
Molecular Typing
Hepatitis B e Antigens
Metabolic Diseases
Glycosylated Hemoglobin A
Surface Antigens
Hepatitis B Surface Antigens
Age of Onset
Hepatitis B virus
Immunoglobulin G
Alleles
Insulin
Infection
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Leonardi, S., Vitaliti, G., Garozzo, M. T., Miraglia del Giudice, M., Marseglia, G., & La Rosa, M. (2012). Hepatitis B vaccination failure in children with diabetes mellitus? The debate continues. Human Vaccines and Immunotherapeutics, 8(4), 448-452.

Hepatitis B vaccination failure in children with diabetes mellitus? The debate continues. / Leonardi, Salvatore; Vitaliti, Giovanna; Garozzo, Maria Teresa; Miraglia del Giudice, Michele; Marseglia, Gianluigi; La Rosa, Mario.

In: Human Vaccines and Immunotherapeutics, Vol. 8, No. 4, 04.2012, p. 448-452.

Research output: Contribution to journalArticle

Leonardi, S, Vitaliti, G, Garozzo, MT, Miraglia del Giudice, M, Marseglia, G & La Rosa, M 2012, 'Hepatitis B vaccination failure in children with diabetes mellitus? The debate continues.', Human Vaccines and Immunotherapeutics, vol. 8, no. 4, pp. 448-452.
Leonardi S, Vitaliti G, Garozzo MT, Miraglia del Giudice M, Marseglia G, La Rosa M. Hepatitis B vaccination failure in children with diabetes mellitus? The debate continues. Human Vaccines and Immunotherapeutics. 2012 Apr;8(4):448-452.
Leonardi, Salvatore ; Vitaliti, Giovanna ; Garozzo, Maria Teresa ; Miraglia del Giudice, Michele ; Marseglia, Gianluigi ; La Rosa, Mario. / Hepatitis B vaccination failure in children with diabetes mellitus? The debate continues. In: Human Vaccines and Immunotherapeutics. 2012 ; Vol. 8, No. 4. pp. 448-452.
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