Hepatitis B virus (HBV) infection and liver disease after allogeneic bone marrow transplantation: A report of 30 cases

A. Locasciulli; A. Bacigalupo; M. T. Van Lint; L. Chemello; P. Po tisso; D. Occhini; C. Uderzo; H. M. Shulman; B. Portmann; A. M. Marmo nt; A. Alberti

Hepatitis B virus (HBV) infection and liver disease after allogeneic bone marrow transplantation: A report of 30 cases

A. Locasciulli, A. Bacigalupo, M. T. Van Lint, L. Chemello, P. Po tisso, D. Occhini, C. Uderzo, H. M. Shulman, B. Portmann, A. M. Marmo nt, A. Alberti

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Among 145 consecutive patients undergoing bone marrow transplantation (BMT) for leukemia or aplastic anemia, 30 (21%) were found positive for hepatitis B surface antigen (HBsAg) in serum either before or after BMT. Their serologic profile and clinical outcome are described. Nine out of 30 patients were HBsAg positive before BMT: four were chronic carriers and five were found HBsAg+ at transplant. Three of the former and one of the five latter patients remained persistently HBsAg+ after transplant with signs of liver disease; none developed liver failure, indicating that HBsAg positivity is not an absolute contra-indication to BMT. Among the remaining 21 patients, HBsAg was detected early (n=12) or late (n=9) after transplant. All 21 cleared the antigen during follow-up and liver disease was either mild and asymptomatic (nine cases) or clinically overt (12 cases), but none had life-threatening liver disease. Several HBV-infected patients were constantly serologic pattern of HBV markers in BMT patients is unpredictable. HBV infection was rarely associated with severe hepatitis and HBsAg carriage.

Original language	English
Pages (from-to)	25-29
Number of pages	5
Journal	Bone Marrow Transplantation
Volume	6
Issue number	1
Publication status	Published - 1990

ASJC Scopus subject areas

Hematology
Transplantation

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Hepatitis B virus (HBV) infection and liver disease after allogeneic bone marrow transplantation : A report of 30 cases. / Locasciulli, A.; Bacigalupo, A.; Van Lint, M. T.; Chemello, L.; Po tisso, P.; Occhini, D.; Uderzo, C.; Shulman, H. M.; Portmann, B.; Marmo nt, A. M.; Alberti, A.

In: Bone Marrow Transplantation, Vol. 6, No. 1, 1990, p. 25-29.

Research output: Contribution to journal › Article › peer-review

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title = "Hepatitis B virus (HBV) infection and liver disease after allogeneic bone marrow transplantation: A report of 30 cases",

abstract = "Among 145 consecutive patients undergoing bone marrow transplantation (BMT) for leukemia or aplastic anemia, 30 (21%) were found positive for hepatitis B surface antigen (HBsAg) in serum either before or after BMT. Their serologic profile and clinical outcome are described. Nine out of 30 patients were HBsAg positive before BMT: four were chronic carriers and five were found HBsAg+ at transplant. Three of the former and one of the five latter patients remained persistently HBsAg+ after transplant with signs of liver disease; none developed liver failure, indicating that HBsAg positivity is not an absolute contra-indication to BMT. Among the remaining 21 patients, HBsAg was detected early (n=12) or late (n=9) after transplant. All 21 cleared the antigen during follow-up and liver disease was either mild and asymptomatic (nine cases) or clinically overt (12 cases), but none had life-threatening liver disease. Several HBV-infected patients were constantly serologic pattern of HBV markers in BMT patients is unpredictable. HBV infection was rarely associated with severe hepatitis and HBsAg carriage.",

author = "A. Locasciulli and A. Bacigalupo and {Van Lint}, {M. T.} and L. Chemello and {Po tisso}, P. and D. Occhini and C. Uderzo and Shulman, {H. M.} and B. Portmann and {Marmo nt}, {A. M.} and A. Alberti",

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AU - Locasciulli, A.

AU - Bacigalupo, A.

AU - Van Lint, M. T.

AU - Chemello, L.

AU - Po tisso, P.

AU - Occhini, D.

AU - Uderzo, C.

AU - Shulman, H. M.

AU - Portmann, B.

AU - Marmo nt, A. M.

AU - Alberti, A.

PY - 1990

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N2 - Among 145 consecutive patients undergoing bone marrow transplantation (BMT) for leukemia or aplastic anemia, 30 (21%) were found positive for hepatitis B surface antigen (HBsAg) in serum either before or after BMT. Their serologic profile and clinical outcome are described. Nine out of 30 patients were HBsAg positive before BMT: four were chronic carriers and five were found HBsAg+ at transplant. Three of the former and one of the five latter patients remained persistently HBsAg+ after transplant with signs of liver disease; none developed liver failure, indicating that HBsAg positivity is not an absolute contra-indication to BMT. Among the remaining 21 patients, HBsAg was detected early (n=12) or late (n=9) after transplant. All 21 cleared the antigen during follow-up and liver disease was either mild and asymptomatic (nine cases) or clinically overt (12 cases), but none had life-threatening liver disease. Several HBV-infected patients were constantly serologic pattern of HBV markers in BMT patients is unpredictable. HBV infection was rarely associated with severe hepatitis and HBsAg carriage.

AB - Among 145 consecutive patients undergoing bone marrow transplantation (BMT) for leukemia or aplastic anemia, 30 (21%) were found positive for hepatitis B surface antigen (HBsAg) in serum either before or after BMT. Their serologic profile and clinical outcome are described. Nine out of 30 patients were HBsAg positive before BMT: four were chronic carriers and five were found HBsAg+ at transplant. Three of the former and one of the five latter patients remained persistently HBsAg+ after transplant with signs of liver disease; none developed liver failure, indicating that HBsAg positivity is not an absolute contra-indication to BMT. Among the remaining 21 patients, HBsAg was detected early (n=12) or late (n=9) after transplant. All 21 cleared the antigen during follow-up and liver disease was either mild and asymptomatic (nine cases) or clinically overt (12 cases), but none had life-threatening liver disease. Several HBV-infected patients were constantly serologic pattern of HBV markers in BMT patients is unpredictable. HBV infection was rarely associated with severe hepatitis and HBsAg carriage.

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