Hepatitis B virus (HBV)/hepatitis D virus (HDV) coinfection in outbreaks of acute hepatitis in the Peruvian amazon basin: The roles of HDV genotype III and HBV genotype F

John L. Casey, Grazia A. Niro, Ronald E. Engle, Antonio Vega, Humberto Gomez, Michael McCarthy, Douglas M. Watts, K. Craig Hyams, John L. Gerin

Research output: Contribution to journalArticlepeer-review

Abstract

Recurring outbreaks of acute hepatitis have been a significant cause of morbidity and mortality among Peruvian military personnel stationed in the Amazon Basin region of Peru. The role of hepatitis B virus (HBV) and hepatitis D virus (HDV) infection was investigated as the possible cause of acute hepatitis among 88 military patients stationed at four different jungle outposts during 1992-1993. Analysis of serum markers indicated that 95% (84/88) had evidence of acute HBV infection; 64% (54/84) were also infected with HDV. Genetic analysis of PCR-amplified HDV and HBV fragments showed exclusively HDV genotype III and HBV genotype F. Furthermore, HDV RNA sequences were similar among patients from the same outpost but different from those at other jungle locations. The data suggested focal sources of HDV infection in the jungle environment of the outposts and, further, confirmed the unique association of HDV genotype III with severe cases of human disease in northern South America.

Original languageEnglish
Pages (from-to)920-926
Number of pages7
JournalJournal of Infectious Diseases
Volume174
Issue number5
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Fingerprint Dive into the research topics of 'Hepatitis B virus (HBV)/hepatitis D virus (HDV) coinfection in outbreaks of acute hepatitis in the Peruvian amazon basin: The roles of HDV genotype III and HBV genotype F'. Together they form a unique fingerprint.

Cite this