Hepatitis B virus preC mutants in human hepatocellular carcinoma tissues

M. Clementi, A. Manzin, S. Paolucci, S. Menzo, P. Bagnarelli, G. Carloni, I. Bearzi

Research output: Contribution to journalArticle

Abstract

A comparative analysis of preC sequences of hepatitis B virus (HBV) in human hepatoma (hepatocellular carcinoma; HCC) tissues and non-tumoral liver samples from HCC patients was performed. Ten out of 17 HCC tissue samples exhibited an amino acid substitution at the level of the distal cysteine residue of the HBV preC region, while generation of a TAG translational stop codon was observed in 4 of these samples. Interestingly, substitution of the distal cysteine residue was not observed in non-tumoral liver (available from 8 of the 17 patients), thus suggesting either that a selection among different HBV variants occurs in HCC cells, or that modifications to the conformation and stability of the HBV capsid protein may play a role in the process of selection and escape of transformed liver cells.

Original languageEnglish
Pages (from-to)297-301
Number of pages5
JournalResearch in Virology
Volume144
Issue numberC
DOIs
Publication statusPublished - 1993

Keywords

  • HBV, Hepatocarcinoma, Pre-core
  • Mutants, Cysteine residue

ASJC Scopus subject areas

  • Immunology
  • Virology

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