TY - JOUR
T1 - Hepatitis C and double-hit B cell lymphoma successfully treated by antiviral therapy
AU - Galati, Giovanni
AU - Rampa, Lorenzo
AU - Vespasiani Gentilucci, U.
AU - Marino, Mirella
AU - Pisani, Francesco
AU - Cota, Carlo
AU - Guidi, Alessandro
AU - Picardi, Antonio
PY - 2016
Y1 - 2016
N2 - B cells lymphoma is one of the most challenging extrahepatic manifestations of hepatitis C virus (HCV). Recently, a new kind of B-cell lymphoma, named doublehit B (DHL), was characterized with an aggressive clinical course whereas a potential association with HCV was not investigated. The new antiviral direct agents (DAAs) against HCV are effective and curative in the majority of HCV infections. We report the first case, to our knowledge, of DHL and HCV-infection successfully treated by new DAAs. According to our experience, a DHL must be suspected in case of HCV-related lymphoma, and an early diagnosis could direct towards a different hematological management because a worse prognosis might be expected. A possible effect of DAAs on DHL regression should be investigated, but eradicating HCV would avoid life-threatening reactivation of viral hepatitis during pharmacological immunosuppression in oncohaematological diseases.
AB - B cells lymphoma is one of the most challenging extrahepatic manifestations of hepatitis C virus (HCV). Recently, a new kind of B-cell lymphoma, named doublehit B (DHL), was characterized with an aggressive clinical course whereas a potential association with HCV was not investigated. The new antiviral direct agents (DAAs) against HCV are effective and curative in the majority of HCV infections. We report the first case, to our knowledge, of DHL and HCV-infection successfully treated by new DAAs. According to our experience, a DHL must be suspected in case of HCV-related lymphoma, and an early diagnosis could direct towards a different hematological management because a worse prognosis might be expected. A possible effect of DAAs on DHL regression should be investigated, but eradicating HCV would avoid life-threatening reactivation of viral hepatitis during pharmacological immunosuppression in oncohaematological diseases.
KW - Chronic hepatitis C
KW - Direct antiviral agents
KW - Double hit lymphoma
KW - Hepatitis C
KW - Lymphoma
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U2 - 10.4254/wjh.v8.i29.1244
DO - 10.4254/wjh.v8.i29.1244
M3 - Article
VL - 8
SP - 1244
EP - 1250
JO - World Journal of Hepatology
JF - World Journal of Hepatology
SN - 1948-5182
IS - 29
ER -