Hepatitis C and double-hit B cell lymphoma successfully treated by antiviral therapy

Giovanni Galati, Lorenzo Rampa, U. Vespasiani Gentilucci, Mirella Marino, Francesco Pisani, Carlo Cota, Alessandro Guidi, Antonio Picardi

Research output: Contribution to journalArticlepeer-review


B cells lymphoma is one of the most challenging extrahepatic manifestations of hepatitis C virus (HCV). Recently, a new kind of B-cell lymphoma, named doublehit B (DHL), was characterized with an aggressive clinical course whereas a potential association with HCV was not investigated. The new antiviral direct agents (DAAs) against HCV are effective and curative in the majority of HCV infections. We report the first case, to our knowledge, of DHL and HCV-infection successfully treated by new DAAs. According to our experience, a DHL must be suspected in case of HCV-related lymphoma, and an early diagnosis could direct towards a different hematological management because a worse prognosis might be expected. A possible effect of DAAs on DHL regression should be investigated, but eradicating HCV would avoid life-threatening reactivation of viral hepatitis during pharmacological immunosuppression in oncohaematological diseases.

Original languageEnglish
Pages (from-to)1244-1250
Number of pages7
JournalWorld Journal of Hepatology
Issue number29
Publication statusPublished - 2016


  • Chronic hepatitis C
  • Direct antiviral agents
  • Double hit lymphoma
  • Hepatitis C
  • Lymphoma

ASJC Scopus subject areas

  • Hepatology


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