Hepatitis C antibody in patients with chronic liver disease and hepatocellular carcinoma

M. Colombo, M. G. Rumi, M. F. Donato, M. A. Tommasini, E. Del Ninno, G. Ronchi, G. Kuo, M. Houghton

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatitis C virus (HCV) is the major etiologic agent of parenterally transmitted non-A,non-B hepatitis. To determine whether there is a relationship between this virus agent and hepatocellular carcinoma (HCC), the sera of patients with HCC and chronic hepatitis were assessed using a sensitive immunoassay for HCV antibody. Anti-HCV was detected in 65% of 132 patients with HCC, without any relationship with the presence of the hepatitis B surface antigen (HBsAg). The prevalence (74%) of anti-HCV was high, as expected in patients with putative non-A,non-B cirrhosis also. The prevalence of anti-HCV was less in patients with HBsAg-positive cirrhosis (28%) and in patients with disease not related to viral hepatitis and healthy controls (8%). These data suggest, but do not prove, that HCV is an important factor associated with HCC.

Original languageEnglish
Pages (from-to)1130-1133
Number of pages4
JournalDigestive Diseases and Sciences
Volume36
Issue number8
DOIs
Publication statusPublished - Aug 1991

Keywords

  • cirrhosis
  • hepatitis C virus
  • hepatocellular carcinoma
  • non-A, non-B hepatitis

ASJC Scopus subject areas

  • Gastroenterology

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