Hepatitis C, cryoglobulinemia, and cutaneous vasculitis associated with unusual and serious manifestations

Patricia Méndez, Kia Saeian, K. Rajender Reddy, Zobair M. Younossi, Francisco Kerdel, Salvatore Badalamenti, Lennox J. Jeffers, Eugene R. Schiff

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Hepatitis C viral infection is currently the leading cause of chronic hepatitis and cirrhosis. It also is a major predisposing factor for the development of hepatocellular carcinoma. It is estimated that approximately 1-2% of patients with hepatitis C infection have nonhepatic manifestations that are protean in nature. In this report, we describe six unusual cases of nonhepatic manifestations: abdominal vasculitis in two, peripheral neuropathy in two, and one patient each with central nervous system vasculitis and necrotizing cutaneous vasculitis. All patients had cutaneous vasculitis and cryoglobulinemia. None of our patients had cirrhosis, yet three of the six patients died. Because of the severe manifestations, aggressive therapy was instituted with interferon, immunosuppressive medications, i.v. immunoglobulin, and plasmapheresis. Our report underscores the importance of recognizing nonhepatic manifestations in patients with hepatitis C infection that may be associated with high morbidity and mortality.

Original languageEnglish
Pages (from-to)2489-2493
Number of pages5
JournalAmerican Journal of Gastroenterology
Volume96
Issue number8
DOIs
Publication statusPublished - 2001

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Cryoglobulinemia
Hepatitis C
Vasculitis
Skin
Fibrosis
Central Nervous System Vasculitis
Plasmapheresis
Peripheral Nervous System Diseases
Virus Diseases
Chronic Hepatitis
Immunosuppressive Agents
Infection
Causality
Interferons
Immunoglobulins
Hepatocellular Carcinoma
Morbidity
Mortality

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hepatitis C, cryoglobulinemia, and cutaneous vasculitis associated with unusual and serious manifestations. / Méndez, Patricia; Saeian, Kia; Reddy, K. Rajender; Younossi, Zobair M.; Kerdel, Francisco; Badalamenti, Salvatore; Jeffers, Lennox J.; Schiff, Eugene R.

In: American Journal of Gastroenterology, Vol. 96, No. 8, 2001, p. 2489-2493.

Research output: Contribution to journalArticle

Méndez, Patricia ; Saeian, Kia ; Reddy, K. Rajender ; Younossi, Zobair M. ; Kerdel, Francisco ; Badalamenti, Salvatore ; Jeffers, Lennox J. ; Schiff, Eugene R. / Hepatitis C, cryoglobulinemia, and cutaneous vasculitis associated with unusual and serious manifestations. In: American Journal of Gastroenterology. 2001 ; Vol. 96, No. 8. pp. 2489-2493.
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