Hepatitis C viraemia and liver disease in symptom-free individuals with anti-HCV

A. Alberti, G. Morsica, L. Chemello, D. Cavalletto, F. Noventa, P. Pontisso, A. Ruol

Research output: Contribution to journalArticle

Abstract

There is controversy about clinical management of patients who persistently have antibodies to hepatitis C virus (anti-HCV) but who have no symptoms and signs of liver disease. We have taken liver biopsy samples from 23 such patients (16 of whom had normal alanine aminotransferase [ALT] values) to assess prevalence of liver disease and to see whether anti-HCV and HCV-RNA correlated with histological findings. 16 patients had histological evidence of chronic hepatitis, which was not predicted by serum ALT or by the pattern of specificity of anti-HCV. All 16 cases with hepatitis C viraemia (HCV-RNA detected by polymerase chain reaction), including 9 with normal ALT, had chronic hepatitis on biopsy (p

Original languageEnglish
Pages (from-to)697-698
Number of pages2
JournalLancet
Volume340
Issue number8821
DOIs
Publication statusPublished - Sep 19 1992

ASJC Scopus subject areas

  • Medicine(all)

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    Alberti, A., Morsica, G., Chemello, L., Cavalletto, D., Noventa, F., Pontisso, P., & Ruol, A. (1992). Hepatitis C viraemia and liver disease in symptom-free individuals with anti-HCV. Lancet, 340(8821), 697-698. https://doi.org/10.1016/0140-6736(92)92234-7