Hepatitis C Virus

A. J. Thompson, P. Clark, A. Aghemo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In 2009, genome-wide association studies identified key roles for IL28B and ITPA polymorphisms in predicting HCV treatment outcomes using pegylated interferonα and ribavirin therapy. The IL28B polymorphism is strongly associated with antiviral efficacy of interferon-based HCV therapy, as well as with the spontaneous clearance of acute HCV infection. Very recently, it was proposed that IL28B polymorphisms actually tag a functional variant that affects the novel IFNL4 gene. Two functional ITPA variants determine the risk of ribavirin-induced hemolytic anemia. Personalized medicine is now a reality for chronic HCV patients, and IL28B genotyping has been incorporated into the clinical algorithm for individuals considering antiviral therapy.

Original languageEnglish
Title of host publicationHandbook of Pharmacogenomics and Stratified Medicine
PublisherElsevier Inc.
Pages859-877
Number of pages19
ISBN (Print)9780123868831, 9780123868824
DOIs
Publication statusPublished - May 6 2014

Keywords

  • Anemia
  • IFNL4
  • IL28B
  • Inosine triphosphatase
  • Interferon
  • Interleukin-28B
  • ITPA
  • Lambda
  • Ribavirin

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Thompson, A. J., Clark, P., & Aghemo, A. (2014). Hepatitis C Virus. In Handbook of Pharmacogenomics and Stratified Medicine (pp. 859-877). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-386882-4.00037-2