Hepatitis C virus and B-cell non-Hodgkin lymphomas

An Italian multicenter case-control study

Alfonso Mele, Alessandro Pulsoni, Elvira Bianco, Pellegrino Musto, Andrè Szklo, Maria Grazia Sanpaolo, Emilio Lannitto, Amalia De Renzo, Bruno Martino, Vincenzo Liso, Cristina Andrizzi, Simona Pusterla, Fausto Dore, Maddalena Maresca, Maria Rapicetta, Fabrizio Marcucci, Franco Mandelli, Silvia Franceschi

Research output: Contribution to journalArticle

244 Citations (Scopus)

Abstract

The existence of an association between infection with hepatitis C virus (HCV) and B-cell non-Hodgkin lymphoma (B-NHL) remains controversial, largely because previous studies were based on prevalent case series or comparisons with less than optimal control groups. This hospital-based case-control study was conducted from January 1998 through February 2001 to evaluate the association between HCV infection and B-NHL of different types. Cases were consecutive patients with a new diagnosis of B-NHL; controls were patients from other departments of the same hospitals. Both groups were interviewed using a standardized questionnaire. The prevalence of HCV infection was calculated by histologic type of B-NHL and clinical behavior (indolent or aggressive). Adjusted odds ratio (OR) and HCV-attributable risk (AR) were estimated. HCV prevalence was 17.5% among the 400 lymphoma patients and 5.6% among the 396 controls. The OR of B-NHL (patients vs controls), adjusted by age, sex, level of education, and place of birth, was 3.1 (95% confidence interval [CI], 1.8-5.2); an OR indicative of positive association was found for indolent and aggressive B-NHL. The estimated AR was 4.6%. This study confirms an association between HCV and B-NHL. In Italy, 1 of 20 instances of B-NHL may be attributable to HCV infection and may, thus, benefit from antiviral treatment.

Original languageEnglish
Pages (from-to)996-999
Number of pages4
JournalBlood
Volume102
Issue number3
DOIs
Publication statusPublished - Aug 1 2003

Fingerprint

B-Cell Lymphoma
Hepatitis B
Viruses
Hepacivirus
Non-Hodgkin's Lymphoma
Case-Control Studies
Cells
Virus Diseases
Odds Ratio
Sex Education
Hospital Departments
Antiviral Agents
Italy
Education
Lymphoma
Confidence Intervals
Control Groups
Infection

ASJC Scopus subject areas

  • Hematology

Cite this

Mele, A., Pulsoni, A., Bianco, E., Musto, P., Szklo, A., Grazia Sanpaolo, M., ... Franceschi, S. (2003). Hepatitis C virus and B-cell non-Hodgkin lymphomas: An Italian multicenter case-control study. Blood, 102(3), 996-999. https://doi.org/10.1182/blood-2002-10-3230

Hepatitis C virus and B-cell non-Hodgkin lymphomas : An Italian multicenter case-control study. / Mele, Alfonso; Pulsoni, Alessandro; Bianco, Elvira; Musto, Pellegrino; Szklo, Andrè; Grazia Sanpaolo, Maria; Lannitto, Emilio; De Renzo, Amalia; Martino, Bruno; Liso, Vincenzo; Andrizzi, Cristina; Pusterla, Simona; Dore, Fausto; Maresca, Maddalena; Rapicetta, Maria; Marcucci, Fabrizio; Mandelli, Franco; Franceschi, Silvia.

In: Blood, Vol. 102, No. 3, 01.08.2003, p. 996-999.

Research output: Contribution to journalArticle

Mele, A, Pulsoni, A, Bianco, E, Musto, P, Szklo, A, Grazia Sanpaolo, M, Lannitto, E, De Renzo, A, Martino, B, Liso, V, Andrizzi, C, Pusterla, S, Dore, F, Maresca, M, Rapicetta, M, Marcucci, F, Mandelli, F & Franceschi, S 2003, 'Hepatitis C virus and B-cell non-Hodgkin lymphomas: An Italian multicenter case-control study', Blood, vol. 102, no. 3, pp. 996-999. https://doi.org/10.1182/blood-2002-10-3230
Mele A, Pulsoni A, Bianco E, Musto P, Szklo A, Grazia Sanpaolo M et al. Hepatitis C virus and B-cell non-Hodgkin lymphomas: An Italian multicenter case-control study. Blood. 2003 Aug 1;102(3):996-999. https://doi.org/10.1182/blood-2002-10-3230
Mele, Alfonso ; Pulsoni, Alessandro ; Bianco, Elvira ; Musto, Pellegrino ; Szklo, Andrè ; Grazia Sanpaolo, Maria ; Lannitto, Emilio ; De Renzo, Amalia ; Martino, Bruno ; Liso, Vincenzo ; Andrizzi, Cristina ; Pusterla, Simona ; Dore, Fausto ; Maresca, Maddalena ; Rapicetta, Maria ; Marcucci, Fabrizio ; Mandelli, Franco ; Franceschi, Silvia. / Hepatitis C virus and B-cell non-Hodgkin lymphomas : An Italian multicenter case-control study. In: Blood. 2003 ; Vol. 102, No. 3. pp. 996-999.
@article{7e6d34bf18a34a94b2e9bb1bcaf7c3a9,
title = "Hepatitis C virus and B-cell non-Hodgkin lymphomas: An Italian multicenter case-control study",
abstract = "The existence of an association between infection with hepatitis C virus (HCV) and B-cell non-Hodgkin lymphoma (B-NHL) remains controversial, largely because previous studies were based on prevalent case series or comparisons with less than optimal control groups. This hospital-based case-control study was conducted from January 1998 through February 2001 to evaluate the association between HCV infection and B-NHL of different types. Cases were consecutive patients with a new diagnosis of B-NHL; controls were patients from other departments of the same hospitals. Both groups were interviewed using a standardized questionnaire. The prevalence of HCV infection was calculated by histologic type of B-NHL and clinical behavior (indolent or aggressive). Adjusted odds ratio (OR) and HCV-attributable risk (AR) were estimated. HCV prevalence was 17.5{\%} among the 400 lymphoma patients and 5.6{\%} among the 396 controls. The OR of B-NHL (patients vs controls), adjusted by age, sex, level of education, and place of birth, was 3.1 (95{\%} confidence interval [CI], 1.8-5.2); an OR indicative of positive association was found for indolent and aggressive B-NHL. The estimated AR was 4.6{\%}. This study confirms an association between HCV and B-NHL. In Italy, 1 of 20 instances of B-NHL may be attributable to HCV infection and may, thus, benefit from antiviral treatment.",
author = "Alfonso Mele and Alessandro Pulsoni and Elvira Bianco and Pellegrino Musto and Andr{\`e} Szklo and {Grazia Sanpaolo}, Maria and Emilio Lannitto and {De Renzo}, Amalia and Bruno Martino and Vincenzo Liso and Cristina Andrizzi and Simona Pusterla and Fausto Dore and Maddalena Maresca and Maria Rapicetta and Fabrizio Marcucci and Franco Mandelli and Silvia Franceschi",
year = "2003",
month = "8",
day = "1",
doi = "10.1182/blood-2002-10-3230",
language = "English",
volume = "102",
pages = "996--999",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "3",

}

TY - JOUR

T1 - Hepatitis C virus and B-cell non-Hodgkin lymphomas

T2 - An Italian multicenter case-control study

AU - Mele, Alfonso

AU - Pulsoni, Alessandro

AU - Bianco, Elvira

AU - Musto, Pellegrino

AU - Szklo, Andrè

AU - Grazia Sanpaolo, Maria

AU - Lannitto, Emilio

AU - De Renzo, Amalia

AU - Martino, Bruno

AU - Liso, Vincenzo

AU - Andrizzi, Cristina

AU - Pusterla, Simona

AU - Dore, Fausto

AU - Maresca, Maddalena

AU - Rapicetta, Maria

AU - Marcucci, Fabrizio

AU - Mandelli, Franco

AU - Franceschi, Silvia

PY - 2003/8/1

Y1 - 2003/8/1

N2 - The existence of an association between infection with hepatitis C virus (HCV) and B-cell non-Hodgkin lymphoma (B-NHL) remains controversial, largely because previous studies were based on prevalent case series or comparisons with less than optimal control groups. This hospital-based case-control study was conducted from January 1998 through February 2001 to evaluate the association between HCV infection and B-NHL of different types. Cases were consecutive patients with a new diagnosis of B-NHL; controls were patients from other departments of the same hospitals. Both groups were interviewed using a standardized questionnaire. The prevalence of HCV infection was calculated by histologic type of B-NHL and clinical behavior (indolent or aggressive). Adjusted odds ratio (OR) and HCV-attributable risk (AR) were estimated. HCV prevalence was 17.5% among the 400 lymphoma patients and 5.6% among the 396 controls. The OR of B-NHL (patients vs controls), adjusted by age, sex, level of education, and place of birth, was 3.1 (95% confidence interval [CI], 1.8-5.2); an OR indicative of positive association was found for indolent and aggressive B-NHL. The estimated AR was 4.6%. This study confirms an association between HCV and B-NHL. In Italy, 1 of 20 instances of B-NHL may be attributable to HCV infection and may, thus, benefit from antiviral treatment.

AB - The existence of an association between infection with hepatitis C virus (HCV) and B-cell non-Hodgkin lymphoma (B-NHL) remains controversial, largely because previous studies were based on prevalent case series or comparisons with less than optimal control groups. This hospital-based case-control study was conducted from January 1998 through February 2001 to evaluate the association between HCV infection and B-NHL of different types. Cases were consecutive patients with a new diagnosis of B-NHL; controls were patients from other departments of the same hospitals. Both groups were interviewed using a standardized questionnaire. The prevalence of HCV infection was calculated by histologic type of B-NHL and clinical behavior (indolent or aggressive). Adjusted odds ratio (OR) and HCV-attributable risk (AR) were estimated. HCV prevalence was 17.5% among the 400 lymphoma patients and 5.6% among the 396 controls. The OR of B-NHL (patients vs controls), adjusted by age, sex, level of education, and place of birth, was 3.1 (95% confidence interval [CI], 1.8-5.2); an OR indicative of positive association was found for indolent and aggressive B-NHL. The estimated AR was 4.6%. This study confirms an association between HCV and B-NHL. In Italy, 1 of 20 instances of B-NHL may be attributable to HCV infection and may, thus, benefit from antiviral treatment.

UR - http://www.scopus.com/inward/record.url?scp=0042243586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042243586&partnerID=8YFLogxK

U2 - 10.1182/blood-2002-10-3230

DO - 10.1182/blood-2002-10-3230

M3 - Article

VL - 102

SP - 996

EP - 999

JO - Blood

JF - Blood

SN - 0006-4971

IS - 3

ER -