Hepatitis C virus and non-Hodgkin's lymphoma: Biology, epidemiology and therapy

Gabriele Pozzato, Francesca Zorat, Stefania Bonetto, Cesare Mazzaro

Research output: Contribution to journalArticle

Abstract

Although the association between the hepatitis C virus and B-cell non-Hodgkin's lymphomas is still controversial, there is increasing evidence of the role of this virus in several B-cell lymphoproliferative disorders, whose prototype is mixed cryoglobulinemia. The aim of the present paper was to provide an overview of the biological mechanisms involved in the development of B-cell disorders in the course of chronic hepatitis C virus infection. The link between this virus and non-Hodgkin's lymphomas is also considered from an epidemiological point of view, and the great regional differences in the prevalence of hepatitis C-associated lymphomas are discussed. Finally, the role of antiviral therapy and suggestions about the most appropriate, currently available, therapeutic approaches are also discussed.

Original languageEnglish
Pages (from-to)249-260
Number of pages12
JournalOncology Reviews
Volume1
Issue number1
Publication statusPublished - May 2007

Fingerprint

Hepacivirus
Non-Hodgkin's Lymphoma
Epidemiology
B-Lymphocytes
Viruses
Cryoglobulinemia
Lymphoproliferative Disorders
B-Cell Lymphoma
Chronic Hepatitis C
Virus Diseases
Hepatitis C
Hepatitis B
Antiviral Agents
Lymphoma
Therapeutics

Keywords

  • Hepatitis C virus
  • Interferon
  • Mixed cryoglobulinemia
  • Non-Hodgkin's lymphoma
  • Ribavirin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Pozzato, G., Zorat, F., Bonetto, S., & Mazzaro, C. (2007). Hepatitis C virus and non-Hodgkin's lymphoma: Biology, epidemiology and therapy. Oncology Reviews, 1(1), 249-260.

Hepatitis C virus and non-Hodgkin's lymphoma : Biology, epidemiology and therapy. / Pozzato, Gabriele; Zorat, Francesca; Bonetto, Stefania; Mazzaro, Cesare.

In: Oncology Reviews, Vol. 1, No. 1, 05.2007, p. 249-260.

Research output: Contribution to journalArticle

Pozzato, G, Zorat, F, Bonetto, S & Mazzaro, C 2007, 'Hepatitis C virus and non-Hodgkin's lymphoma: Biology, epidemiology and therapy', Oncology Reviews, vol. 1, no. 1, pp. 249-260.
Pozzato G, Zorat F, Bonetto S, Mazzaro C. Hepatitis C virus and non-Hodgkin's lymphoma: Biology, epidemiology and therapy. Oncology Reviews. 2007 May;1(1):249-260.
Pozzato, Gabriele ; Zorat, Francesca ; Bonetto, Stefania ; Mazzaro, Cesare. / Hepatitis C virus and non-Hodgkin's lymphoma : Biology, epidemiology and therapy. In: Oncology Reviews. 2007 ; Vol. 1, No. 1. pp. 249-260.
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