Hepatitis C virus and non-Hodgkin's lymphoma: Biology, epidemiology and therapy

Gabriele Pozzato, Francesca Zorat, Stefania Bonetto, Cesare Mazzaro

Research output: Contribution to journalArticle

Abstract

Although the association between the hepatitis C virus and B-cell non-Hodgkin's lymphomas is still controversial, there is increasing evidence of the role of this virus in several B-cell lymphoproliferative disorders, whose prototype is mixed cryoglobulinemia. The aim of the present paper was to provide an overview of the biological mechanisms involved in the development of B-cell disorders in the course of chronic hepatitis C virus infection. The link between this virus and non-Hodgkin's lymphomas is also considered from an epidemiological point of view, and the great regional differences in the prevalence of hepatitis C-associated lymphomas are discussed. Finally, the role of antiviral therapy and suggestions about the most appropriate, currently available, therapeutic approaches are also discussed.

Original languageEnglish
Pages (from-to)249-260
Number of pages12
JournalOncology Reviews
Volume1
Issue number1
Publication statusPublished - May 2007

Keywords

  • Hepatitis C virus
  • Interferon
  • Mixed cryoglobulinemia
  • Non-Hodgkin's lymphoma
  • Ribavirin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Pozzato, G., Zorat, F., Bonetto, S., & Mazzaro, C. (2007). Hepatitis C virus and non-Hodgkin's lymphoma: Biology, epidemiology and therapy. Oncology Reviews, 1(1), 249-260.