Hepatitis C virus and non-Hodgkin's lymphoma: Biology, epidemiology and therapy

Gabriele Pozzato, Francesca Zorat, Stefania Bonetto, Cesare Mazzaro

Research output: Contribution to journalArticlepeer-review


Although the association between the hepatitis C virus and B-cell non-Hodgkin's lymphomas is still controversial, there is increasing evidence of the role of this virus in several B-cell lymphoproliferative disorders, whose prototype is mixed cryoglobulinemia. The aim of the present paper was to provide an overview of the biological mechanisms involved in the development of B-cell disorders in the course of chronic hepatitis C virus infection. The link between this virus and non-Hodgkin's lymphomas is also considered from an epidemiological point of view, and the great regional differences in the prevalence of hepatitis C-associated lymphomas are discussed. Finally, the role of antiviral therapy and suggestions about the most appropriate, currently available, therapeutic approaches are also discussed.

Original languageEnglish
Pages (from-to)249-260
Number of pages12
JournalOncology Reviews
Issue number1
Publication statusPublished - May 2007


  • Hepatitis C virus
  • Interferon
  • Mixed cryoglobulinemia
  • Non-Hodgkin's lymphoma
  • Ribavirin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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