Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study

S. Franceschi, J. Polesel, M. Rickenbach, L. Dal Maso, N. M. Probst-Hensch, C. Fux, M. Cavassini, B. Hasse, A. Kofler, B. Ledergerber, P. Erb, G. M. Clifford, M. Battegay, E. Bernasconi, J. Böni, H. Bucher, P. Bürgisser, S. Cattacin, M. Cavassini, R. DubsM. Egger, L. Elzi, P. Erb, M. Fischer, M. Flepp, A. Fontana, P. Francioli, H. Furrer, M. Gorgievski, H. Günthard, B. Hirschel, B. Hösli, C. Kahlert, L. Kaiser, U. Karrer, O. Keiser, C. Kind, T. Klimkait, B. Ledergerber, B. Martinez, N. Müller, D. Nadal, M. Opravil, F. Paccaud, G. Pantaleo, L. Perrin, J. C. Piffaretti, M. Rickenbach, C. Rudin, P. Schmid, D. Schultze, J. Schüpbach, R. Speck, P. Taffé, P. Tarr, A. Telenti, A. Trkola, P. Vernazza, R. Weber, S. Yerly

Research output: Contribution to journalArticlepeer-review

Abstract

Infections with hepatitis C virus (HCV) and, possibly, hepatitis B virus (HBV) are associated with an increased risk of non-Hodgkin's lymphoma (NHL) in the general population, but little information is available on the relationship between hepatitis viruses and NHL among people with HIV (PHIV). We conducted a matched case-control study nested in the Swiss HIV Cohort Study (SHCS). Two hundred and ninety-eight NHL cases and 889 control subjects were matched by SHCS centre, gender, age group, CD4+ count at enrolment, and length of follow-up. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were computed using logistic regression to evaluate the association between NHL and seropositivity for antibodies against HCV (anti-HCV) and hepatitis B core antigen (anti-HBc), and for hepatitis B surface antigen (HBsAg). Anti-HCV was not associated with increased NHL risk overall (OR=1.05; 95% CI: 0.63-1.75), or in different strata of CD4+ count, age or gender. Only among men having sex with men was an association with anti-HCV found (OR=2.37; 95% CI: 1.03-5.43). No relationships between NHL risk and anti-HBc or HBsAg emerged. Coinfection with HIV and HCV or HBV did not increase NHL risk compared to HIV alone in the SHCS.

Original languageEnglish
Pages (from-to)1598-1602
Number of pages5
JournalBritish Journal of Cancer
Volume95
Issue number11
DOIs
Publication statusPublished - Dec 4 2006

Keywords

  • Hepatitis C virus
  • HIV
  • Non-Hodgkin's lymphoma
  • Switzerland

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study'. Together they form a unique fingerprint.

Cite this