Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study

S. Franceschi; J. Polesel; M. Rickenbach; L. Dal Maso; N. M. Probst-Hensch; C. Fux; M. Cavassini; B. Hasse; A. Kofler; B. Ledergerber; P. Erb; G. M. Clifford; M. Battegay; E. Bernasconi; J. Böni; H. Bucher; P. Bürgisser; S. Cattacin; M. Cavassini; R. Dubs; M. Egger; L. Elzi; P. Erb; M. Fischer; M. Flepp; A. Fontana; P. Francioli; H. Furrer; M. Gorgievski; H. Günthard; B. Hirschel; B. Hösli; C. Kahlert; L. Kaiser; U. Karrer; O. Keiser; C. Kind; T. Klimkait; B. Ledergerber; B. Martinez; N. Müller; D. Nadal; M. Opravil; F. Paccaud; G. Pantaleo; L. Perrin; J. C. Piffaretti; M. Rickenbach; C. Rudin; P. Schmid; D. Schultze; J. Schüpbach; R. Speck; P. Taffé; P. Tarr; A. Telenti; A. Trkola; P. Vernazza; R. Weber; S. Yerly

doi:10.1038/sj.bjc.6603472

Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study

S. Franceschi, J. Polesel, M. Rickenbach, L. Dal Maso, N. M. Probst-Hensch, C. Fux, M. Cavassini, B. Hasse, A. Kofler, B. Ledergerber, P. Erb, G. M. Clifford, M. Battegay, E. Bernasconi, J. Böni, H. Bucher, P. Bürgisser, S. Cattacin, M. Cavassini, R. DubsM. Egger, L. Elzi, P. Erb, M. Fischer, M. Flepp, A. Fontana, P. Francioli, H. Furrer, M. Gorgievski, H. Günthard, B. Hirschel, B. Hösli, C. Kahlert, L. Kaiser, U. Karrer, O. Keiser, C. Kind, T. Klimkait, B. Ledergerber, B. Martinez, N. Müller, D. Nadal, M. Opravil, F. Paccaud, G. Pantaleo, L. Perrin, J. C. Piffaretti, M. Rickenbach, C. Rudin, P. Schmid, D. Schultze, J. Schüpbach, R. Speck, P. Taffé, P. Tarr, A. Telenti, A. Trkola, P. Vernazza, R. Weber, S. Yerly

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

Infections with hepatitis C virus (HCV) and, possibly, hepatitis B virus (HBV) are associated with an increased risk of non-Hodgkin's lymphoma (NHL) in the general population, but little information is available on the relationship between hepatitis viruses and NHL among people with HIV (PHIV). We conducted a matched case-control study nested in the Swiss HIV Cohort Study (SHCS). Two hundred and ninety-eight NHL cases and 889 control subjects were matched by SHCS centre, gender, age group, CD4+ count at enrolment, and length of follow-up. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were computed using logistic regression to evaluate the association between NHL and seropositivity for antibodies against HCV (anti-HCV) and hepatitis B core antigen (anti-HBc), and for hepatitis B surface antigen (HBsAg). Anti-HCV was not associated with increased NHL risk overall (OR=1.05; 95% CI: 0.63-1.75), or in different strata of CD4+ count, age or gender. Only among men having sex with men was an association with anti-HCV found (OR=2.37; 95% CI: 1.03-5.43). No relationships between NHL risk and anti-HBc or HBsAg emerged. Coinfection with HIV and HCV or HBV did not increase NHL risk compared to HIV alone in the SHCS.

Original language	English
Pages (from-to)	1598-1602
Number of pages	5
Journal	British Journal of Cancer
Volume	95
Issue number	11
DOIs	https://doi.org/10.1038/sj.bjc.6603472
Publication status	Published - Dec 4 2006

Keywords

Hepatitis C virus
HIV
Non-Hodgkin's lymphoma
Switzerland

ASJC Scopus subject areas

Cancer Research
Oncology

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10.1038/sj.bjc.6603472

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Franceschi, S., Polesel, J., Rickenbach, M., Dal Maso, L., Probst-Hensch, N. M., Fux, C., Cavassini, M., Hasse, B., Kofler, A., Ledergerber, B., Erb, P., Clifford, G. M., Battegay, M., Bernasconi, E., Böni, J., Bucher, H., Bürgisser, P., Cattacin, S., Cavassini, M., ... Yerly, S. (2006). Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study. British Journal of Cancer, 95(11), 1598-1602. https://doi.org/10.1038/sj.bjc.6603472

Franceschi, S, Polesel, J, Rickenbach, M, Dal Maso, L, Probst-Hensch, NM, Fux, C, Cavassini, M, Hasse, B, Kofler, A, Ledergerber, B, Erb, P, Clifford, GM, Battegay, M, Bernasconi, E, Böni, J, Bucher, H, Bürgisser, P, Cattacin, S, Cavassini, M, Dubs, R, Egger, M, Elzi, L, Erb, P, Fischer, M, Flepp, M, Fontana, A, Francioli, P, Furrer, H, Gorgievski, M, Günthard, H, Hirschel, B, Hösli, B, Kahlert, C, Kaiser, L, Karrer, U, Keiser, O, Kind, C, Klimkait, T, Ledergerber, B, Martinez, B, Müller, N, Nadal, D, Opravil, M, Paccaud, F, Pantaleo, G, Perrin, L, Piffaretti, JC, Rickenbach, M, Rudin, C, Schmid, P, Schultze, D, Schüpbach, J, Speck, R, Taffé, P, Tarr, P, Telenti, A, Trkola, A, Vernazza, P, Weber, R & Yerly, S 2006, 'Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study', British Journal of Cancer, vol. 95, no. 11, pp. 1598-1602. https://doi.org/10.1038/sj.bjc.6603472

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abstract = "Infections with hepatitis C virus (HCV) and, possibly, hepatitis B virus (HBV) are associated with an increased risk of non-Hodgkin's lymphoma (NHL) in the general population, but little information is available on the relationship between hepatitis viruses and NHL among people with HIV (PHIV). We conducted a matched case-control study nested in the Swiss HIV Cohort Study (SHCS). Two hundred and ninety-eight NHL cases and 889 control subjects were matched by SHCS centre, gender, age group, CD4+ count at enrolment, and length of follow-up. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were computed using logistic regression to evaluate the association between NHL and seropositivity for antibodies against HCV (anti-HCV) and hepatitis B core antigen (anti-HBc), and for hepatitis B surface antigen (HBsAg). Anti-HCV was not associated with increased NHL risk overall (OR=1.05; 95% CI: 0.63-1.75), or in different strata of CD4+ count, age or gender. Only among men having sex with men was an association with anti-HCV found (OR=2.37; 95% CI: 1.03-5.43). No relationships between NHL risk and anti-HBc or HBsAg emerged. Coinfection with HIV and HCV or HBV did not increase NHL risk compared to HIV alone in the SHCS.",

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author = "S. Franceschi and J. Polesel and M. Rickenbach and {Dal Maso}, L. and Probst-Hensch, {N. M.} and C. Fux and M. Cavassini and B. Hasse and A. Kofler and B. Ledergerber and P. Erb and Clifford, {G. M.} and M. Battegay and E. Bernasconi and J. B{\"o}ni and H. Bucher and P. B{\"u}rgisser and S. Cattacin and M. Cavassini and R. Dubs and M. Egger and L. Elzi and P. Erb and M. Fischer and M. Flepp and A. Fontana and P. Francioli and H. Furrer and M. Gorgievski and H. G{\"u}nthard and B. Hirschel and B. H{\"o}sli and C. Kahlert and L. Kaiser and U. Karrer and O. Keiser and C. Kind and T. Klimkait and B. Ledergerber and B. Martinez and N. M{\"u}ller and D. Nadal and M. Opravil and F. Paccaud and G. Pantaleo and L. Perrin and Piffaretti, {J. C.} and M. Rickenbach and C. Rudin and P. Schmid and D. Schultze and J. Sch{\"u}pbach and R. Speck and P. Taff{\'e} and P. Tarr and A. Telenti and A. Trkola and P. Vernazza and R. Weber and S. Yerly",

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doi = "10.1038/sj.bjc.6603472",

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T2 - Findings from the Swiss HIV Cohort Study

AU - Franceschi, S.

AU - Polesel, J.

AU - Rickenbach, M.

AU - Dal Maso, L.

AU - Probst-Hensch, N. M.

AU - Fux, C.

AU - Cavassini, M.

AU - Hasse, B.

AU - Kofler, A.

AU - Ledergerber, B.

AU - Erb, P.

AU - Clifford, G. M.

AU - Battegay, M.

AU - Bernasconi, E.

AU - Böni, J.

AU - Bucher, H.

AU - Bürgisser, P.

AU - Cattacin, S.

AU - Cavassini, M.

AU - Dubs, R.

AU - Egger, M.

AU - Elzi, L.

AU - Erb, P.

AU - Fischer, M.

AU - Flepp, M.

AU - Fontana, A.

AU - Francioli, P.

AU - Furrer, H.

AU - Gorgievski, M.

AU - Günthard, H.

AU - Hirschel, B.

AU - Hösli, B.

AU - Kahlert, C.

AU - Kaiser, L.

AU - Karrer, U.

AU - Keiser, O.

AU - Kind, C.

AU - Klimkait, T.

AU - Ledergerber, B.

AU - Martinez, B.

AU - Müller, N.

AU - Nadal, D.

AU - Opravil, M.

AU - Paccaud, F.

AU - Pantaleo, G.

AU - Perrin, L.

AU - Piffaretti, J. C.

AU - Rickenbach, M.

AU - Rudin, C.

AU - Schmid, P.

AU - Schultze, D.

AU - Schüpbach, J.

AU - Speck, R.

AU - Taffé, P.

AU - Tarr, P.

AU - Telenti, A.

AU - Trkola, A.

AU - Vernazza, P.

AU - Weber, R.

AU - Yerly, S.

PY - 2006/12/4

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N2 - Infections with hepatitis C virus (HCV) and, possibly, hepatitis B virus (HBV) are associated with an increased risk of non-Hodgkin's lymphoma (NHL) in the general population, but little information is available on the relationship between hepatitis viruses and NHL among people with HIV (PHIV). We conducted a matched case-control study nested in the Swiss HIV Cohort Study (SHCS). Two hundred and ninety-eight NHL cases and 889 control subjects were matched by SHCS centre, gender, age group, CD4+ count at enrolment, and length of follow-up. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were computed using logistic regression to evaluate the association between NHL and seropositivity for antibodies against HCV (anti-HCV) and hepatitis B core antigen (anti-HBc), and for hepatitis B surface antigen (HBsAg). Anti-HCV was not associated with increased NHL risk overall (OR=1.05; 95% CI: 0.63-1.75), or in different strata of CD4+ count, age or gender. Only among men having sex with men was an association with anti-HCV found (OR=2.37; 95% CI: 1.03-5.43). No relationships between NHL risk and anti-HBc or HBsAg emerged. Coinfection with HIV and HCV or HBV did not increase NHL risk compared to HIV alone in the SHCS.

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KW - Hepatitis C virus

KW - HIV

KW - Non-Hodgkin's lymphoma

KW - Switzerland

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Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study

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Keywords

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