Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study

S. Franceschi; J. Polesel; M. Rickenbach; L. Dal Maso; N. M. Probst-Hensch; C. Fux; M. Cavassini; B. Hasse; A. Kofler; B. Ledergerber; P. Erb; G. M. Clifford; M. Battegay; E. Bernasconi; J. Böni; H. Bucher; P. Bürgisser; S. Cattacin; M. Cavassini; R. Dubs; M. Egger; L. Elzi; P. Erb; M. Fischer; M. Flepp; A. Fontana; P. Francioli; H. Furrer; M. Gorgievski; H. Günthard; B. Hirschel; B. Hösli; C. Kahlert; L. Kaiser; U. Karrer; O. Keiser; C. Kind; T. Klimkait; B. Ledergerber; B. Martinez; N. Müller; D. Nadal; M. Opravil; F. Paccaud; G. Pantaleo; L. Perrin; J. C. Piffaretti; M. Rickenbach; C. Rudin; P. Schmid; D. Schultze; J. Schüpbach; R. Speck; P. Taffé; P. Tarr; A. Telenti; A. Trkola; P. Vernazza; R. Weber; S. Yerly

doi:10.1038/sj.bjc.6603472

Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study

S. Franceschi, J. Polesel, M. Rickenbach, L. Dal Maso, N. M. Probst-Hensch, C. Fux, M. Cavassini, B. Hasse, A. Kofler, B. Ledergerber, P. Erb, G. M. Clifford, M. Battegay, E. Bernasconi, J. Böni, H. Bucher, P. Bürgisser, S. Cattacin, M. Cavassini, R. DubsM. Egger, L. Elzi, P. Erb, M. Fischer, M. Flepp, A. Fontana, P. Francioli, H. Furrer, M. Gorgievski, H. Günthard, B. Hirschel, B. Hösli, C. Kahlert, L. Kaiser, U. Karrer, O. Keiser, C. Kind, T. Klimkait, B. Ledergerber, B. Martinez, N. Müller, D. Nadal, M. Opravil, F. Paccaud, G. Pantaleo, L. Perrin, J. C. Piffaretti, M. Rickenbach, C. Rudin, P. Schmid, D. Schultze, J. Schüpbach, R. Speck, P. Taffé, P. Tarr, A. Telenti, A. Trkola, P. Vernazza, R. Weber, S. Yerly

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

Infections with hepatitis C virus (HCV) and, possibly, hepatitis B virus (HBV) are associated with an increased risk of non-Hodgkin's lymphoma (NHL) in the general population, but little information is available on the relationship between hepatitis viruses and NHL among people with HIV (PHIV). We conducted a matched case-control study nested in the Swiss HIV Cohort Study (SHCS). Two hundred and ninety-eight NHL cases and 889 control subjects were matched by SHCS centre, gender, age group, CD4+ count at enrolment, and length of follow-up. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were computed using logistic regression to evaluate the association between NHL and seropositivity for antibodies against HCV (anti-HCV) and hepatitis B core antigen (anti-HBc), and for hepatitis B surface antigen (HBsAg). Anti-HCV was not associated with increased NHL risk overall (OR=1.05; 95% CI: 0.63-1.75), or in different strata of CD4+ count, age or gender. Only among men having sex with men was an association with anti-HCV found (OR=2.37; 95% CI: 1.03-5.43). No relationships between NHL risk and anti-HBc or HBsAg emerged. Coinfection with HIV and HCV or HBV did not increase NHL risk compared to HIV alone in the SHCS.

Original language	English
Pages (from-to)	1598-1602
Number of pages	5
Journal	British Journal of Cancer
Volume	95
Issue number	11
DOIs	https://doi.org/10.1038/sj.bjc.6603472
Publication status	Published - Dec 4 2006

Keywords

Hepatitis C virus
HIV
Non-Hodgkin's lymphoma
Switzerland

ASJC Scopus subject areas

Cancer Research
Oncology

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Franceschi, S., Polesel, J., Rickenbach, M., Dal Maso, L., Probst-Hensch, N. M., Fux, C., Cavassini, M., Hasse, B., Kofler, A., Ledergerber, B., Erb, P., Clifford, G. M., Battegay, M., Bernasconi, E., Böni, J., Bucher, H., Bürgisser, P., Cattacin, S., Cavassini, M., ... Yerly, S. (2006). Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study. British Journal of Cancer, 95(11), 1598-1602. https://doi.org/10.1038/sj.bjc.6603472

Hepatitis C virus and non-Hodgkin's lymphoma : Findings from the Swiss HIV Cohort Study. / Franceschi, S.; Polesel, J.; Rickenbach, M.; Dal Maso, L.; Probst-Hensch, N. M.; Fux, C.; Cavassini, M.; Hasse, B.; Kofler, A.; Ledergerber, B.; Erb, P.; Clifford, G. M.; Battegay, M.; Bernasconi, E.; Böni, J.; Bucher, H.; Bürgisser, P.; Cattacin, S.; Cavassini, M.; Dubs, R.; Egger, M.; Elzi, L.; Erb, P.; Fischer, M.; Flepp, M.; Fontana, A.; Francioli, P.; Furrer, H.; Gorgievski, M.; Günthard, H.; Hirschel, B.; Hösli, B.; Kahlert, C.; Kaiser, L.; Karrer, U.; Keiser, O.; Kind, C.; Klimkait, T.; Ledergerber, B.; Martinez, B.; Müller, N.; Nadal, D.; Opravil, M.; Paccaud, F.; Pantaleo, G.; Perrin, L.; Piffaretti, J. C.; Rickenbach, M.; Rudin, C.; Schmid, P.; Schultze, D.; Schüpbach, J.; Speck, R.; Taffé, P.; Tarr, P.; Telenti, A.; Trkola, A.; Vernazza, P.; Weber, R.; Yerly, S.

In: British Journal of Cancer, Vol. 95, No. 11, 04.12.2006, p. 1598-1602.

Research output: Contribution to journal › Article › peer-review

Franceschi, S, Polesel, J, Rickenbach, M, Dal Maso, L, Probst-Hensch, NM, Fux, C, Cavassini, M, Hasse, B, Kofler, A, Ledergerber, B, Erb, P, Clifford, GM, Battegay, M, Bernasconi, E, Böni, J, Bucher, H, Bürgisser, P, Cattacin, S, Cavassini, M, Dubs, R, Egger, M, Elzi, L, Erb, P, Fischer, M, Flepp, M, Fontana, A, Francioli, P, Furrer, H, Gorgievski, M, Günthard, H, Hirschel, B, Hösli, B, Kahlert, C, Kaiser, L, Karrer, U, Keiser, O, Kind, C, Klimkait, T, Ledergerber, B, Martinez, B, Müller, N, Nadal, D, Opravil, M, Paccaud, F, Pantaleo, G, Perrin, L, Piffaretti, JC, Rickenbach, M, Rudin, C, Schmid, P, Schultze, D, Schüpbach, J, Speck, R, Taffé, P, Tarr, P, Telenti, A, Trkola, A, Vernazza, P, Weber, R & Yerly, S 2006, 'Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study', British Journal of Cancer, vol. 95, no. 11, pp. 1598-1602. https://doi.org/10.1038/sj.bjc.6603472

Franceschi, S. ; Polesel, J. ; Rickenbach, M. ; Dal Maso, L. ; Probst-Hensch, N. M. ; Fux, C. ; Cavassini, M. ; Hasse, B. ; Kofler, A. ; Ledergerber, B. ; Erb, P. ; Clifford, G. M. ; Battegay, M. ; Bernasconi, E. ; Böni, J. ; Bucher, H. ; Bürgisser, P. ; Cattacin, S. ; Cavassini, M. ; Dubs, R. ; Egger, M. ; Elzi, L. ; Erb, P. ; Fischer, M. ; Flepp, M. ; Fontana, A. ; Francioli, P. ; Furrer, H. ; Gorgievski, M. ; Günthard, H. ; Hirschel, B. ; Hösli, B. ; Kahlert, C. ; Kaiser, L. ; Karrer, U. ; Keiser, O. ; Kind, C. ; Klimkait, T. ; Ledergerber, B. ; Martinez, B. ; Müller, N. ; Nadal, D. ; Opravil, M. ; Paccaud, F. ; Pantaleo, G. ; Perrin, L. ; Piffaretti, J. C. ; Rickenbach, M. ; Rudin, C. ; Schmid, P. ; Schultze, D. ; Schüpbach, J. ; Speck, R. ; Taffé, P. ; Tarr, P. ; Telenti, A. ; Trkola, A. ; Vernazza, P. ; Weber, R. ; Yerly, S. / Hepatitis C virus and non-Hodgkin's lymphoma : Findings from the Swiss HIV Cohort Study. In: British Journal of Cancer. 2006 ; Vol. 95, No. 11. pp. 1598-1602.

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abstract = "Infections with hepatitis C virus (HCV) and, possibly, hepatitis B virus (HBV) are associated with an increased risk of non-Hodgkin's lymphoma (NHL) in the general population, but little information is available on the relationship between hepatitis viruses and NHL among people with HIV (PHIV). We conducted a matched case-control study nested in the Swiss HIV Cohort Study (SHCS). Two hundred and ninety-eight NHL cases and 889 control subjects were matched by SHCS centre, gender, age group, CD4+ count at enrolment, and length of follow-up. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were computed using logistic regression to evaluate the association between NHL and seropositivity for antibodies against HCV (anti-HCV) and hepatitis B core antigen (anti-HBc), and for hepatitis B surface antigen (HBsAg). Anti-HCV was not associated with increased NHL risk overall (OR=1.05; 95% CI: 0.63-1.75), or in different strata of CD4+ count, age or gender. Only among men having sex with men was an association with anti-HCV found (OR=2.37; 95% CI: 1.03-5.43). No relationships between NHL risk and anti-HBc or HBsAg emerged. Coinfection with HIV and HCV or HBV did not increase NHL risk compared to HIV alone in the SHCS.",

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T2 - Findings from the Swiss HIV Cohort Study

AU - Franceschi, S.

AU - Polesel, J.

AU - Rickenbach, M.

AU - Dal Maso, L.

AU - Probst-Hensch, N. M.

AU - Fux, C.

AU - Cavassini, M.

AU - Hasse, B.

AU - Kofler, A.

AU - Ledergerber, B.

AU - Erb, P.

AU - Clifford, G. M.

AU - Battegay, M.

AU - Bernasconi, E.

AU - Böni, J.

AU - Bucher, H.

AU - Bürgisser, P.

AU - Cattacin, S.

AU - Cavassini, M.

AU - Dubs, R.

AU - Egger, M.

AU - Elzi, L.

AU - Erb, P.

AU - Fischer, M.

AU - Flepp, M.

AU - Fontana, A.

AU - Francioli, P.

AU - Furrer, H.

AU - Gorgievski, M.

AU - Günthard, H.

AU - Hirschel, B.

AU - Hösli, B.

AU - Kahlert, C.

AU - Kaiser, L.

AU - Karrer, U.

AU - Keiser, O.

AU - Kind, C.

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AU - Rudin, C.

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AU - Schultze, D.

AU - Schüpbach, J.

AU - Speck, R.

AU - Taffé, P.

AU - Tarr, P.

AU - Telenti, A.

AU - Trkola, A.

AU - Vernazza, P.

AU - Weber, R.

AU - Yerly, S.

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KW - HIV

KW - Non-Hodgkin's lymphoma

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Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study

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Keywords

ASJC Scopus subject areas

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