TY - JOUR
T1 - Hepatitis C virus and non-Hodgkin's lymphomas
T2 - Meta-analysis of epidemiology data and therapy options
AU - Pozzato, Gabriele
AU - Mazzaro, Cesare
AU - Dal Maso, Luigino
AU - Mauro, Endri
AU - Zorat, Francesca
AU - Moratelli, Giulia
AU - Bulian, Pietro
AU - Serraino, Diego
AU - Gattei, Valter
PY - 2016
Y1 - 2016
N2 - Hepatitis C virus (HCV) is a global health problem affecting a large fraction of the world's population: This virus is able to determine both hepatic and extrahepatic diseases. Mixed cryoglobulinemia, a B-cell "benign" lymphoproliferative disorders, represents the most closely related as well as the most investigated HCV-related extrahepatic disorder. Since this virus is able to determine extrahepatic [non-Hodgkin's lymphoma (NHL)] as well as hepatic malignancies (hepatocellular carcinoma), HCV has been included among human cancer viruses. The most common histological types of HCV-associated NHL are the marginal zone, the lymphoplasmacytic and diffuse large cell lymphomas. The role of the HCV in the pathogenesis of the B-cell lymphoproliferative disorders is confirmed also by the responsiveness of the NHL to antiviral therapy. The purpose of this review is to provide an overview of the recent literature and a meta analysis of the epidemiology data, to explain the role of HCV in the development of NHL's lymphoma. Furthermore, the possibility to treat these HCV-related NHL with theantiviral therapy or with other therapeutic options, like chemotherapy, is also discussed.
AB - Hepatitis C virus (HCV) is a global health problem affecting a large fraction of the world's population: This virus is able to determine both hepatic and extrahepatic diseases. Mixed cryoglobulinemia, a B-cell "benign" lymphoproliferative disorders, represents the most closely related as well as the most investigated HCV-related extrahepatic disorder. Since this virus is able to determine extrahepatic [non-Hodgkin's lymphoma (NHL)] as well as hepatic malignancies (hepatocellular carcinoma), HCV has been included among human cancer viruses. The most common histological types of HCV-associated NHL are the marginal zone, the lymphoplasmacytic and diffuse large cell lymphomas. The role of the HCV in the pathogenesis of the B-cell lymphoproliferative disorders is confirmed also by the responsiveness of the NHL to antiviral therapy. The purpose of this review is to provide an overview of the recent literature and a meta analysis of the epidemiology data, to explain the role of HCV in the development of NHL's lymphoma. Furthermore, the possibility to treat these HCV-related NHL with theantiviral therapy or with other therapeutic options, like chemotherapy, is also discussed.
KW - Alpha-interferon
KW - Hepatitis C virus
KW - Hepatitis C virus genotypes
KW - Non-Hodgkin's lymphoma
UR - http://www.scopus.com/inward/record.url?scp=84954421809&partnerID=8YFLogxK
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U2 - 10.4254/wjh.v8.i2.107
DO - 10.4254/wjh.v8.i2.107
M3 - Article
AN - SCOPUS:84954421809
VL - 8
SP - 107
EP - 116
JO - World Journal of Hepatology
JF - World Journal of Hepatology
SN - 1948-5182
IS - 2
ER -