Hepatitis C virus and non-Hodgkin's lymphomas: Meta-analysis of epidemiology data and therapy options

Gabriele Pozzato, Cesare Mazzaro, Luigino Dal Maso, Endri Mauro, Francesca Zorat, Giulia Moratelli, Pietro Bulian, Diego Serraino, Valter Gattei

Research output: Contribution to journalArticle

Abstract

Hepatitis C virus (HCV) is a global health problem affecting a large fraction of the world's population: This virus is able to determine both hepatic and extrahepatic diseases. Mixed cryoglobulinemia, a B-cell "benign" lymphoproliferative disorders, represents the most closely related as well as the most investigated HCV-related extrahepatic disorder. Since this virus is able to determine extrahepatic [non-Hodgkin's lymphoma (NHL)] as well as hepatic malignancies (hepatocellular carcinoma), HCV has been included among human cancer viruses. The most common histological types of HCV-associated NHL are the marginal zone, the lymphoplasmacytic and diffuse large cell lymphomas. The role of the HCV in the pathogenesis of the B-cell lymphoproliferative disorders is confirmed also by the responsiveness of the NHL to antiviral therapy. The purpose of this review is to provide an overview of the recent literature and a meta analysis of the epidemiology data, to explain the role of HCV in the development of NHL's lymphoma. Furthermore, the possibility to treat these HCV-related NHL with theantiviral therapy or with other therapeutic options, like chemotherapy, is also discussed.

Original languageEnglish
Pages (from-to)107-116
Number of pages10
JournalWorld Journal of Hepatology
Volume8
Issue number2
DOIs
Publication statusPublished - 2016

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Keywords

  • Alpha-interferon
  • Hepatitis C virus
  • Hepatitis C virus genotypes
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Hepatology

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