Hepatitis C virus chronic infection and oral lichen planus: An Italian case-control study

Michele Giuliani, Carlo Lajolo, Mario Carlo Miani, Giovanni Lodi, Pasquale Minenna, Alessandra Mangia

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: The aim of the study was to investigate the possible epidemiological relationship between hepatitis C virus (HCV) chronic infection and oral lichen planus (OLP) in centre-south Italy. METHODS: In a case-control study three groups of patients were investigated: group 1 (82 patients): patients with histologically confirmed OLP were tested for HCV infection; group 2 (165 patients): patients with chronic HCV infection were examined for OLP; group 3 (466 participants): control group: healthy individuals who had been hospitalized in the Trauma-Orthopaedic Ward and had been tested for HCV. RESULTS: In group 1, 11.4% of the participants were HCV-positive and HCV was found in 10.8% of the patients above 50 years of age. Eight participants (5.5%) of group 2 showed lesions possibly related to OLP: only two had a histology consistent with OLP. In group 3, 5.4% participants had chronic HCV infection, but HCV was found in 10% of the participants of 50 years and above. A weak overall association between HCV and OLP (odds ratio 2.27; 95% confidence interval 0.94, 5.35; P

Original languageEnglish
Pages (from-to)647-652
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number8
Publication statusPublished - Aug 2007


  • Chronic hepatitis
  • Hepatitis C virus
  • Italy
  • Oral lichen planus

ASJC Scopus subject areas

  • Gastroenterology


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