Abstract
Mixed cryoglobulinemia is a systemic disease, almost always associated with hepatitis C virus infection and characterized by purpura and cutaneous vasculitis, asthenia, arthralgias, and often renal and neurological involvement. No significant differences have been described to date in mixed cryoglobulinemia patients with type 1, 2, or 3 hepatitis C virus infection with respect to symptoms, while a higher prevalence of genotype 2a has been reported in patients without clinical and biochemical signs of liver disease or with serum autoantibodies. We examined 33 hepatitis C virus-positive patients with mixed cryoglobulinemia to assess if any clinical or serological feature is related to infection with different genotypes. All subjects underwent viral genotype determination by means of a single-step polymerase chain reaction. Thirteen patients (39%) were infected with hepatitis C virus type lb, 17 (52%) with type 2a or 2adc, and 3 (9%) with type 3. There was a significant difference in the frequency of peripheral nervous system involvement: paresthesias or other symptoms of peripheral neuropathy were less frequent in patients with 2a or 2a/c infection (29%) than in patients with type lb or type 3 infection (88%, P=0.003). Only patients with hepatitis C virus type 2 had urticaria or cutaneous ulcers. These patients also had a lower frequency of arthralgias, lower cryocrit values (P=0.02), and lower serum levels of alanine-aminotransferase and γ-glutamyl-transpeptidase (P
| Original language | English |
|---|---|
| Pages (from-to) | 96-99 |
| Number of pages | 4 |
| Journal | International Journal of Clinical & Laboratory Research |
| Volume | 28 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 1998 |
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Keywords
- Hepatitis C virus genotypes
- Mixed cryoglobulinemia
- Peripheral neuropathy
ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
Hepatitis C virus genotypes and clinical features in hepatitis C virus-related mixed cryoglobulinemia. / Origgi, L.; Vanoli, M.; Lunghi, G.; Carbone, A.; Grasso, M.; Scorza, R.
In: International Journal of Clinical & Laboratory Research, Vol. 28, No. 2, 06.1998, p. 96-99.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hepatitis C virus genotypes and clinical features in hepatitis C virus-related mixed cryoglobulinemia
AU - Origgi, L.
AU - Vanoli, M.
AU - Lunghi, G.
AU - Carbone, A.
AU - Grasso, M.
AU - Scorza, R.
PY - 1998/6
Y1 - 1998/6
N2 - Mixed cryoglobulinemia is a systemic disease, almost always associated with hepatitis C virus infection and characterized by purpura and cutaneous vasculitis, asthenia, arthralgias, and often renal and neurological involvement. No significant differences have been described to date in mixed cryoglobulinemia patients with type 1, 2, or 3 hepatitis C virus infection with respect to symptoms, while a higher prevalence of genotype 2a has been reported in patients without clinical and biochemical signs of liver disease or with serum autoantibodies. We examined 33 hepatitis C virus-positive patients with mixed cryoglobulinemia to assess if any clinical or serological feature is related to infection with different genotypes. All subjects underwent viral genotype determination by means of a single-step polymerase chain reaction. Thirteen patients (39%) were infected with hepatitis C virus type lb, 17 (52%) with type 2a or 2adc, and 3 (9%) with type 3. There was a significant difference in the frequency of peripheral nervous system involvement: paresthesias or other symptoms of peripheral neuropathy were less frequent in patients with 2a or 2a/c infection (29%) than in patients with type lb or type 3 infection (88%, P=0.003). Only patients with hepatitis C virus type 2 had urticaria or cutaneous ulcers. These patients also had a lower frequency of arthralgias, lower cryocrit values (P=0.02), and lower serum levels of alanine-aminotransferase and γ-glutamyl-transpeptidase (P
AB - Mixed cryoglobulinemia is a systemic disease, almost always associated with hepatitis C virus infection and characterized by purpura and cutaneous vasculitis, asthenia, arthralgias, and often renal and neurological involvement. No significant differences have been described to date in mixed cryoglobulinemia patients with type 1, 2, or 3 hepatitis C virus infection with respect to symptoms, while a higher prevalence of genotype 2a has been reported in patients without clinical and biochemical signs of liver disease or with serum autoantibodies. We examined 33 hepatitis C virus-positive patients with mixed cryoglobulinemia to assess if any clinical or serological feature is related to infection with different genotypes. All subjects underwent viral genotype determination by means of a single-step polymerase chain reaction. Thirteen patients (39%) were infected with hepatitis C virus type lb, 17 (52%) with type 2a or 2adc, and 3 (9%) with type 3. There was a significant difference in the frequency of peripheral nervous system involvement: paresthesias or other symptoms of peripheral neuropathy were less frequent in patients with 2a or 2a/c infection (29%) than in patients with type lb or type 3 infection (88%, P=0.003). Only patients with hepatitis C virus type 2 had urticaria or cutaneous ulcers. These patients also had a lower frequency of arthralgias, lower cryocrit values (P=0.02), and lower serum levels of alanine-aminotransferase and γ-glutamyl-transpeptidase (P
KW - Hepatitis C virus genotypes
KW - Mixed cryoglobulinemia
KW - Peripheral neuropathy
UR - http://www.scopus.com/inward/record.url?scp=0031875012&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031875012&partnerID=8YFLogxK
U2 - 10.1007/s005990050026
DO - 10.1007/s005990050026
M3 - Article
C2 - 9689550
AN - SCOPUS:0031875012
VL - 28
SP - 96
EP - 99
JO - Ricerca in Clinica e in Laboratorio
JF - Ricerca in Clinica e in Laboratorio
SN - 0940-5437
IS - 2
ER -