Hepatitis C virus genotypes and clinical features in hepatitis C virus-related mixed cryoglobulinemia

L. Origgi, M. Vanoli, G. Lunghi, A. Carbone, M. Grasso, R. Scorza

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13 Citations (Scopus)

Abstract

Mixed cryoglobulinemia is a systemic disease, almost always associated with hepatitis C virus infection and characterized by purpura and cutaneous vasculitis, asthenia, arthralgias, and often renal and neurological involvement. No significant differences have been described to date in mixed cryoglobulinemia patients with type 1, 2, or 3 hepatitis C virus infection with respect to symptoms, while a higher prevalence of genotype 2a has been reported in patients without clinical and biochemical signs of liver disease or with serum autoantibodies. We examined 33 hepatitis C virus-positive patients with mixed cryoglobulinemia to assess if any clinical or serological feature is related to infection with different genotypes. All subjects underwent viral genotype determination by means of a single-step polymerase chain reaction. Thirteen patients (39%) were infected with hepatitis C virus type lb, 17 (52%) with type 2a or 2adc, and 3 (9%) with type 3. There was a significant difference in the frequency of peripheral nervous system involvement: paresthesias or other symptoms of peripheral neuropathy were less frequent in patients with 2a or 2a/c infection (29%) than in patients with type lb or type 3 infection (88%, P=0.003). Only patients with hepatitis C virus type 2 had urticaria or cutaneous ulcers. These patients also had a lower frequency of arthralgias, lower cryocrit values (P=0.02), and lower serum levels of alanine-aminotransferase and γ-glutamyl-transpeptidase (P

Original languageEnglish
Pages (from-to)96-99
Number of pages4
JournalInternational Journal of Clinical & Laboratory Research
Volume28
Issue number2
DOIs
Publication statusPublished - Jun 1998

Fingerprint

Cryoglobulinemia
Viruses
Hepacivirus
Genotype
Arthralgia
Virus Diseases
gamma-Glutamyltransferase
Polymerase chain reaction
Neurology
Alanine Transaminase
Infection
Liver
Autoantibodies
Skin Ulcer
Asthenia
Purpura
Paresthesia
Urticaria
Peripheral Nervous System
Peripheral Nervous System Diseases

Keywords

  • Hepatitis C virus genotypes
  • Mixed cryoglobulinemia
  • Peripheral neuropathy

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Hepatitis C virus genotypes and clinical features in hepatitis C virus-related mixed cryoglobulinemia. / Origgi, L.; Vanoli, M.; Lunghi, G.; Carbone, A.; Grasso, M.; Scorza, R.

In: International Journal of Clinical & Laboratory Research, Vol. 28, No. 2, 06.1998, p. 96-99.

Research output: Contribution to journalArticle

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