Hepatitis C virus (HCV) genotypes in 373 Italian children with HCV infection: Changing distribution and correlation with clinical features and outcome

F. Bortolotti, M. Resti, M. Marcellini, R. Giacchino, G. Verucchi, G. Nebbia, L. Zancan, M. G. Marazzi, C. Barbera, A. Maccabruni, G. Zuin, G. Maggiore, F. Balli, P. Vajro, L. Lepore, M. Molesini, M. Guido, S. Bartolacci, F. Noventa

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Abstract

Background and aim: Little is known of hepatitis C virus (HCV) genotypes in HCV infected children. This retrospective, multicentre study investigated genotype distribution and correlation with clinical features and outcome in a large series of Italian children. Methods: Between 1990 and 2002, 373 HCV RNA positive children, consecutively recruited in 15 centres, were assayed for genotypes by a commercial line probe assay. Results: The following genotype distribution pattern was recorded: genotype 1b = 41%; 1a = 20%; 2 = 17%; 3 = 14.5%; 4 = 5%; other = 2.5%. The prevalence of genotypes 1b and 2 decreased significantly (p

Original languageEnglish
Pages (from-to)852-857
Number of pages6
JournalGut
Volume54
Issue number6
DOIs
Publication statusPublished - Jun 2005

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ASJC Scopus subject areas

  • Gastroenterology

Cite this

Bortolotti, F., Resti, M., Marcellini, M., Giacchino, R., Verucchi, G., Nebbia, G., Zancan, L., Marazzi, M. G., Barbera, C., Maccabruni, A., Zuin, G., Maggiore, G., Balli, F., Vajro, P., Lepore, L., Molesini, M., Guido, M., Bartolacci, S., & Noventa, F. (2005). Hepatitis C virus (HCV) genotypes in 373 Italian children with HCV infection: Changing distribution and correlation with clinical features and outcome. Gut, 54(6), 852-857. https://doi.org/10.1136/gut.2004.053744