Hepatitis C virus (HCV) hypervariable region 1 complexity does not correlate with severity of liver disease, HCV type, viral load or duration of infection

Francesco Leone, Herve' Zylberberg, Giovanni Squadrito, Bernard Le Guen, Pierre Berthelot, Stanislas Pol, Christian Brechot

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background/Aims: Several studies have suggested that infection with a highly heterogeneous population of hepatitis C virus correlates with a low response rate to interferon. It is still debated, however, whether or not this heterogeneity might be associated with liver disease severity. The aim of this study was to analyse hepatitis C virus genome complexity in patients with various stages of liver disease. Methods: We used polymerase chain reaction-single strand conformation polymorphism (SSCP) analysis to estimate the degree of complexity of the hypervariable region (HVR1) in 95 anti-HCV and serum HCV-RNA positive patients. They were divided into two groups according to Knodell's histological activity index (HAI) grading: 22 with HAI

Original languageEnglish
Pages (from-to)689-694
Number of pages6
JournalJournal of Hepatology
Volume29
Issue number5
DOIs
Publication statusPublished - Nov 1998

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Viral Load
Hepacivirus
Liver Diseases
Infection
Interferons
Genome
RNA
Polymerase Chain Reaction
Serum
Population

Keywords

  • HCV quasispecies
  • Knodell's grading
  • PCR-SSCP analysis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hepatitis C virus (HCV) hypervariable region 1 complexity does not correlate with severity of liver disease, HCV type, viral load or duration of infection. / Leone, Francesco; Zylberberg, Herve'; Squadrito, Giovanni; Le Guen, Bernard; Berthelot, Pierre; Pol, Stanislas; Brechot, Christian.

In: Journal of Hepatology, Vol. 29, No. 5, 11.1998, p. 689-694.

Research output: Contribution to journalArticle

Leone, Francesco ; Zylberberg, Herve' ; Squadrito, Giovanni ; Le Guen, Bernard ; Berthelot, Pierre ; Pol, Stanislas ; Brechot, Christian. / Hepatitis C virus (HCV) hypervariable region 1 complexity does not correlate with severity of liver disease, HCV type, viral load or duration of infection. In: Journal of Hepatology. 1998 ; Vol. 29, No. 5. pp. 689-694.
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