Abstract
Background/Aims: Several studies have suggested that infection with a highly heterogeneous population of hepatitis C virus correlates with a low response rate to interferon. It is still debated, however, whether or not this heterogeneity might be associated with liver disease severity. The aim of this study was to analyse hepatitis C virus genome complexity in patients with various stages of liver disease. Methods: We used polymerase chain reaction-single strand conformation polymorphism (SSCP) analysis to estimate the degree of complexity of the hypervariable region (HVR1) in 95 anti-HCV and serum HCV-RNA positive patients. They were divided into two groups according to Knodell's histological activity index (HAI) grading: 22 with HAI
Original language | English |
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Pages (from-to) | 689-694 |
Number of pages | 6 |
Journal | Journal of Hepatology |
Volume | 29 |
Issue number | 5 |
DOIs | |
Publication status | Published - Nov 1998 |
Keywords
- HCV quasispecies
- Knodell's grading
- PCR-SSCP analysis
ASJC Scopus subject areas
- Gastroenterology