Hepatitis C virus in patients with porphyria cutanea tarda: Relationship to HCV-genotypes

D. Rivanera, D. Lilli, D. Griso, A. Macrì, C. Mancini

Research output: Contribution to journalArticlepeer-review

Abstract

Porphyria cutanea tarda (PCT) is a rare metabolic disorder characterized by an abnormal porphyrin metabolism and typical cutaneous lesions. Recently a strong association between PCT and hepatitis C virus (HCV) has been proposed. Studies in south Europe have shown high prevalence (53 to 91%) of HCV markers in patients with PCT. We studied HCV genotypes in 72 subjects: 40 with PCT and 32 patients with chronic liver disease. A high rate of HCV-RNA positive PCT patients (84%) was observed, reflecting an active HCV replication, the genotypes study showed a prevalence of genotype 1b in PCT patients (61.2%). These findings implicate HCV in the aetiology of PCT-associated liver disease suggesting that hepatitis C serological and virological testing could be indicated in all patients with PCT.

Original languageEnglish
Pages (from-to)329-334
Number of pages6
JournalNew Microbiologica
Volume21
Issue number4
Publication statusPublished - Oct 1998

Keywords

  • HCV genotypes
  • Hepatitis
  • Porphyria cutanea tarda

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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